PMID- 16728268
OWN - NLM
STAT- MEDLINE
DCOM- 20060816
LR  - 20060526
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 67
IP  - 6
DP  - 2006 Jun
TI  - Immunoregulation of autoimmune diseases.
PG  - 446-53
AB  - Since the discovery of human leukocyte antigen (HLA) as a genetic system, the 
      search for the biological function of HLA molecules has been a very intense and 
      attractive area of immunological research. It has been a major factor in the 
      development of our understanding of the role of T cells in the initiation and 
      regulation of autoimmune diseases. The currently increasing incidences of chronic 
      inflammatory diseases, such as allergies but also several autoimmune diseases, 
      possibly due to our Westernized modern life-style, are asking for novel 
      intervention or prevention strategies. Heat shock proteins (or stress proteins) 
      can be an example of relevant microbial antigens with an intrinsic capacity to 
      trigger anti-inflammatory T cell regulation. Heat shock proteins may be part of 
      an ancient system, which includes several stress-induced self-antigens, seen by a 
      self-protective immune system. Peptide-based intervention, including clinical 
      trials with HSP60 and HSP70 peptides, is now an area of intensive clinical 
      research.
FAU - van Eden, Willem
AU  - van Eden W
AD  - Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, 
      Utrecht University, The Netherlands. w.eden@ve.uu.nl
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20060331
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Antigens, Bacterial)
RN  - 0 (Autoantibodies)
RN  - 0 (Bacterial Proteins)
RN  - 0 (Chaperonin 60)
RN  - 0 (HLA Antigens)
RN  - 0 (HSP70 Heat-Shock Proteins)
RN  - 0 (Peptide Fragments)
SB  - IM
MH  - Animals
MH  - Antigen-Presenting Cells/immunology
MH  - Antigens, Bacterial/immunology
MH  - Autoantibodies/immunology
MH  - Autoimmune Diseases/drug therapy/epidemiology/*immunology
MH  - Bacterial Infections/immunology
MH  - Bacterial Proteins/immunology
MH  - Chaperonin 60/immunology
MH  - HLA Antigens/genetics/*immunology
MH  - HSP70 Heat-Shock Proteins/immunology
MH  - Humans
MH  - Immune Tolerance
MH  - Inflammation/immunology/microbiology
MH  - Major Histocompatibility Complex
MH  - Peptide Fragments/therapeutic use
MH  - Polymorphism, Genetic
MH  - T-Lymphocytes/*immunology/microbiology
MH  - T-Lymphocytes, Regulatory/immunology/microbiology
RF  - 40
EDAT- 2006/05/27 09:00
MHDA- 2006/08/17 09:00
CRDT- 2006/05/27 09:00
PHST- 2006/02/21 00:00 [received]
PHST- 2006/05/27 09:00 [pubmed]
PHST- 2006/08/17 09:00 [medline]
PHST- 2006/05/27 09:00 [entrez]
AID - S0198-8859(06)00050-4 [pii]
AID - 10.1016/j.humimm.2006.03.010 [doi]
PST - ppublish
SO  - Hum Immunol. 2006 Jun;67(6):446-53. doi: 10.1016/j.humimm.2006.03.010. Epub 2006 
      Mar 31.