PMID- 16728269
OWN - NLM
STAT- MEDLINE
DCOM- 20060816
LR  - 20131121
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 67
IP  - 6
DP  - 2006 Jun
TI  - HLA and RA revisited: citrullinated food for the SE hypothesis, the DR6 effect, 
      and NIMA.
PG  - 454-9
AB  - An obvious way to unravel the apparently complex association between human 
      leukocyte antigen (HLA) and rheumatoid arthritis (RA) is to reduce the 
      heterogeneity of this multifactorial disease. Recently we have discovered that 
      shared epitope (SE)-positive HLA-DRB1 alleles are exclusively associated with a 
      subgroup of RA patients that test positive for auto-antibodies against cyclic 
      citrullinated peptides. Further studies suggested that SE-positive alleles are 
      classical immune response genes for the development of these antibodies. On the 
      basis of these and other data we formulated a two-hit model for the pathogenesis 
      of RA which incorporates a novel "citrullinated" SE hypothesis. About 5 years ago 
      Zanelli et al. reported that HLA-DR6 (*1301 and *1302) and some other DR alleles 
      that share the DERAA-sequence on amino acids 70-74 of their third hypervariable 
      region are associated with protection from (severe) RA. Recently we corroborated 
      these data in a large prospective cohort study and demonstrated that protection 
      was observed both in the presence and in the absence of a SE susceptibility 
      allele on the other haplotype. Finally we review the state of the art of the 
      association of noninherited maternal HLA antigens with both susceptibility to and 
      protection from RA.
FAU - de Vries, Rene R P
AU  - de Vries RR
AD  - Department of Immunohematology/Bloodtransfusion, Leiden University Medical 
      Center, The Netherlands.
FAU - Huizinga, Tom W J
AU  - Huizinga TW
FAU - Toes, Rene E M
AU  - Toes RE
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20060403
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Autoantibodies)
RN  - 0 (Epitopes)
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DR beta-Chains)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB6 antigen)
RN  - 29VT07BGDA (Citrulline)
SB  - IM
MH  - Arthritis, Rheumatoid/genetics/*immunology
MH  - Autoantibodies/immunology
MH  - Citrulline/*immunology/metabolism
MH  - Epitopes
MH  - Genetic Predisposition to Disease
MH  - HLA Antigens/genetics/*immunology
MH  - HLA-DR Antigens/genetics/immunology
MH  - HLA-DR beta-Chains
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Immunity, Maternally-Acquired
MH  - Models, Immunological
RF  - 39
EDAT- 2006/05/27 09:00
MHDA- 2006/08/17 09:00
CRDT- 2006/05/27 09:00
PHST- 2006/02/21 00:00 [received]
PHST- 2006/05/27 09:00 [pubmed]
PHST- 2006/08/17 09:00 [medline]
PHST- 2006/05/27 09:00 [entrez]
AID - S0198-8859(06)00048-6 [pii]
AID - 10.1016/j.humimm.2006.03.016 [doi]
PST - ppublish
SO  - Hum Immunol. 2006 Jun;67(6):454-9. doi: 10.1016/j.humimm.2006.03.016. Epub 2006 
      Apr 3.