PMID- 16730862
OWN - NLM
STAT- MEDLINE
DCOM- 20060914
LR  - 20061115
IS  - 0197-0186 (Print)
IS  - 0197-0186 (Linking)
VI  - 49
IP  - 2
DP  - 2006 Jul
TI  - CNS dendritic cells: critical participants in CNS inflammation?
PG  - 195-203
AB  - Dendritic cells (DCs) are a heterogeneous population of migratory cells 
      specialized for the uptake, processing, and presentation of antigen to T cells. 
      They consist of a variety of mature subpopulations, classically divided into 
      "lymphoid" and "myeloid" subsets. Although there likely exists significant 
      plasticity and redundancy between DC subpopulations, unique differences have been 
      noted in their abilities for T cell stimulation, tolerance induction, T helper 
      cell polarization, cytokine secretion, and anatomic localization. Although DCs 
      are conspicuously absent from the healthy CNS parenchyma, their presence in the 
      vascular-rich regions of the healthy CNS has been well established and suggests 
      they may have a role in immune surveillance. DCs do accumulate in the CNS 
      parenchyma in a wide range of inflammatory responses including parasite, viral, 
      or bacterial infection and CNS autoimmune disease. They also are present in CNS 
      immune responses without overt T cell involvement, such as the inflammation 
      accompanying CNS injury or neurodegeneration. Controversy remains on the role of 
      CNS DCs during inflammation and whether they differentiate from CNS-resident 
      microglia or infiltrate from a blood-borne population. This review will summarize 
      DC subsets and function, overview the current research on DCs in the healthy and 
      inflamed CNS, and address discrepancies between experimental studies.
FAU - McMahon, Eileen J
AU  - McMahon EJ
AD  - Department of Biology, Westmont College, 955 La Paz Rd, Santa Barbara, CA 93108, 
      United States.
FAU - Bailey, Samantha L
AU  - Bailey SL
FAU - Miller, Stephen D
AU  - Miller SD
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20060530
PL  - England
TA  - Neurochem Int
JT  - Neurochemistry international
JID - 8006959
SB  - IM
MH  - Animals
MH  - Autoimmunity/immunology
MH  - Cell Differentiation/immunology
MH  - Central Nervous System/*immunology/physiopathology
MH  - Dendritic Cells/*immunology
MH  - Encephalitis/*immunology/physiopathology
MH  - Humans
MH  - Immunity, Cellular/*immunology
MH  - Immunologic Surveillance/immunology
MH  - Microglia/immunology
MH  - T-Lymphocytes/*immunology
RF  - 87
EDAT- 2006/05/30 09:00
MHDA- 2006/09/15 09:00
CRDT- 2006/05/30 09:00
PHST- 2005/07/30 00:00 [received]
PHST- 2006/04/07 00:00 [revised]
PHST- 2006/04/08 00:00 [accepted]
PHST- 2006/05/30 09:00 [pubmed]
PHST- 2006/09/15 09:00 [medline]
PHST- 2006/05/30 09:00 [entrez]
AID - S0197-0186(06)00170-7 [pii]
AID - 10.1016/j.neuint.2006.04.004 [doi]
PST - ppublish
SO  - Neurochem Int. 2006 Jul;49(2):195-203. doi: 10.1016/j.neuint.2006.04.004. Epub 
      2006 May 30.