PMID- 16731509
OWN - NLM
STAT- MEDLINE
DCOM- 20060721
LR  - 20220309
IS  - 0896-6273 (Print)
IS  - 0896-6273 (Linking)
VI  - 50
IP  - 5
DP  - 2006 Jun 1
TI  - A multireceptor genetic approach uncovers an ordered integration of VNO sensory 
      inputs in the accessory olfactory bulb.
PG  - 697-709
AB  - Pheromone detection by the vomeronasal organ (VNO) is thought to rely on 
      activation of specific receptors from the V1R and V2R gene families, but the 
      central representation of pheromone receptor activation remains poorly 
      understood. We generated transgenic mouse lines in which projections from 
      multiple populations of VNO neurons, each expressing a distinct V1R, are 
      differentially labeled with fluorescent proteins. This approach revealed that 
      inputs from neurons expressing closely related V1Rs intermingle within shared, 
      spatially conserved domains of the accessory olfactory bulb (AOB). Mitral 
      cell-glomerular connectivity was examined by injecting intracellular dyes into 
      AOB mitral cells and monitoring dendritic contacts with genetically labeled 
      glomeruli. We show that individual mitral cells extend dendrites to glomeruli 
      associated with different, but likely closely related, V1Rs. This organization 
      differs from the labeled line of OR signaling in the main olfactory system and 
      suggests that integration of information may already occur at the level of the 
      AOB.
FAU - Wagner, Shlomo
AU  - Wagner S
AD  - Department of Neurobiology, Hebrew University, Jerusalem 91904, Israel. 
      shlomo@lobster.ls.huji.ac.il
FAU - Gresser, Amy L
AU  - Gresser AL
FAU - Torello, A Thomas
AU  - Torello AT
FAU - Dulac, Catherine
AU  - Dulac C
LA  - eng
GR  - R01 DC003903/DC/NIDCD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Neuron
JT  - Neuron
JID - 8809320
RN  - 0 (Receptors, Pheromone)
SB  - IM
MH  - Animals
MH  - Brain Mapping
MH  - Cell Line
MH  - Dendrites/physiology
MH  - Genes, Reporter
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Transgenic
MH  - Neurons, Afferent/physiology/ultrastructure
MH  - Olfactory Bulb/cytology/*physiology
MH  - Olfactory Pathways/cytology/physiology
MH  - Protein Structure, Tertiary
MH  - Receptors, Pheromone/chemistry/*genetics/*metabolism
MH  - Smell/*physiology
MH  - Vomeronasal Organ/cytology/*physiology
EDAT- 2006/05/30 09:00
MHDA- 2006/07/22 09:00
CRDT- 2006/05/30 09:00
PHST- 2006/02/24 00:00 [received]
PHST- 2006/04/17 00:00 [revised]
PHST- 2006/04/26 00:00 [accepted]
PHST- 2006/05/30 09:00 [pubmed]
PHST- 2006/07/22 09:00 [medline]
PHST- 2006/05/30 09:00 [entrez]
AID - S0896-6273(06)00370-9 [pii]
AID - 10.1016/j.neuron.2006.04.033 [doi]
PST - ppublish
SO  - Neuron. 2006 Jun 1;50(5):697-709. doi: 10.1016/j.neuron.2006.04.033.