PMID- 16732768
OWN - NLM
STAT- MEDLINE
DCOM- 20060731
LR  - 20131121
IS  - 0914-3505 (Print)
IS  - 0914-3505 (Linking)
VI  - 46
IP  - 2
DP  - 2006 Jun
TI  - Cardiovascular malformations induced by prenatal exposure to phenobarbital in 
      rats.
PG  - 97-104
AB  - The effects of prenatal exposure to phenobarbital (PB) on the cardiovascular 
      system were examined in rat fetuses and pups. PB was administered at a dose of 80 
      or 120 mg/kg/day by gavage to Sprague Dawley (SD) rats on two consecutive 
      gestational days (GD): 7-8, 8-9, 9-10, or 10-11. Fetuses were examined for 
      cardiovascular malformations on GD 20. In addition, pups were examined for 
      PB-induced cardiovascular malformations. Incidences of ventricular septal defect 
      (VSD), overriding aorta, double outlet right ventricle and transposition of great 
      arteries were significantly increased in the fetuses whose dams were administered 
      PB at 120 mg/kg on GD 8-9, 9-10 or 10-11. GD 8-11 was the critical period for the 
      cardiovascular malformations associated with administration of PB in rats. 
      Various types of cardiovascular malformations were detected in pups from the 
      PB-administered dam. Severe cardiovascular malformations induced by PB caused 
      deaths on early postnatal days. However, slight malformations such as isolated 
      VSD persisted until weaning, and did not affect postnatal viability.
FAU - Okuda, Hirokazu
AU  - Okuda H
AD  - Japan Bioassay Research Center, Japan Industrial Safety and Health Association, 
      Kanagawa, Japan. h-okuda@jisha.or.jp
FAU - Nagao, Tetsuji
AU  - Nagao T
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Congenit Anom (Kyoto)
JT  - Congenital anomalies
JID - 9306292
RN  - 0 (Excitatory Amino Acid Antagonists)
RN  - YQE403BP4D (Phenobarbital)
SB  - IM
MH  - *Abnormalities, Drug-Induced
MH  - Animals
MH  - Cardiovascular Abnormalities/chemically induced
MH  - Dose-Response Relationship, Drug
MH  - Excitatory Amino Acid Antagonists/*toxicity
MH  - Female
MH  - Heart Defects, Congenital/*chemically induced
MH  - Male
MH  - *Maternal-Fetal Exchange
MH  - Phenobarbital/*toxicity
MH  - Pregnancy
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2006/05/31 09:00
MHDA- 2006/08/01 09:00
CRDT- 2006/05/31 09:00
PHST- 2006/05/31 09:00 [pubmed]
PHST- 2006/08/01 09:00 [medline]
PHST- 2006/05/31 09:00 [entrez]
AID - CGA [pii]
AID - 10.1111/j.1741-4520.2006.00109.x [doi]
PST - ppublish
SO  - Congenit Anom (Kyoto). 2006 Jun;46(2):97-104. doi: 
      10.1111/j.1741-4520.2006.00109.x.