PMID- 16734115
OWN - NLM
STAT- MEDLINE
DCOM- 20061107
LR  - 20161021
IS  - 1110-4902 (Print)
VI  - 11
IP  - 2
DP  - 2004
TI  - Interleukin 16 (IL-16) in asthma and allergic rhinitis. A comparison between 
      upper and lower airways.
PG  - 31-6
AB  - Asthma is a chronic inflammatory disease of bronchial mucosa, in which mast 
      cells, eosinophils and activated T cells are of considerable importance. The 
      increased chemotactic activity for T cells in patients with asthma is mainly 
      attributable to IL-16. A strong association between asthma and allergic rhinitis 
      exists from a clinical and epidemiologic standpoint of view. Although it is clear 
      that the condition of the upper airways has impact on the lower airway 
      physiology, the precise mechanisms underlying this relation are far from being 
      resolved. This work was assessed the role of interleukin 16 (IL-16) in 
      bronchoalveolar lavage (BAL) fluid in both diseases using quantitative sandwich 
      enzyme immuno-assay, and the effect on ventilatory function. The results showed 
      abnormally increased levels of IL-16 (294.4 +/- 15.24 pg/ml), serum eosinophils 
      with absolute count (510.0 +/- 93.57, P>0.05), and total serum IgE (287.9 +/- 
      61.22 IU/ml) using ELFA in patients of combined asthma and rhinitis, than in each 
      of them alone. There was reduction in FEV1 (forced expiratory volume in the first 
      second) in the same group (81.6 +/- 2.01%). There was a negative correlation 
      between BAL IL-16 and FEV1. In conclusion IL-16 may be considered as a marker of 
      severity of airway inflammation.
FAU - Afifi, Salwa S
AU  - Afifi SS
AD  - Microbiology Department, Faculty of Pharmacy, Faculty of Medicine For Girls, 
      Al-Azhar University, Cairo, Egypt.
FAU - ElArab, Amani Ezz
AU  - ElArab AE
FAU - Mostafa, Soad Y
AU  - Mostafa SY
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PL  - Egypt
TA  - Egypt J Immunol
JT  - The Egyptian journal of immunology
JID - 9816016
RN  - 0 (Biomarkers)
RN  - 0 (Interleukin-16)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Asthma/blood/*immunology
MH  - Biomarkers/analysis/blood
MH  - Bronchoalveolar Lavage Fluid/chemistry/immunology
MH  - Eosinophils/*cytology/immunology
MH  - Female
MH  - Forced Expiratory Volume
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Interleukin-16/analysis/*blood
MH  - Leukocyte Count
MH  - Male
MH  - Nasal Cavity/*chemistry/*immunology/physiopathology
MH  - Predictive Value of Tests
MH  - Rhinitis/blood/*immunology
EDAT- 2006/06/01 09:00
MHDA- 2006/11/09 09:00
CRDT- 2006/06/01 09:00
PHST- 2006/06/01 09:00 [pubmed]
PHST- 2006/11/09 09:00 [medline]
PHST- 2006/06/01 09:00 [entrez]
PST - ppublish
SO  - Egypt J Immunol. 2004;11(2):31-6.