PMID- 16734677
OWN - NLM
STAT- MEDLINE
DCOM- 20060802
LR  - 20060531
IS  - 0268-9146 (Print)
IS  - 0268-9146 (Linking)
VI  - 37
IP  - 3
DP  - 2006 Jun
TI  - Fine mapping of genes on sheep chromosome 1 and their association with milk 
      traits.
PG  - 205-10
AB  - On the basis of comparative mapping between cattle/sheep and human for milk trait 
      quantitative trait loci (QTL) on BTA3/OAR1, annexin A9 (ANXA9) and solute carrier 
      family 27 (fatty acid transporter), member 3 (SLC27A3) were selected as candidate 
      genes for fat content (FC) in sheep milk. Two other genes in the same region, 
      cingulin (CGN) and acid phosphatase 6, lysophosphatidic (ACP6), were also 
      considered. DNA fragments of 1931 and 2790 bp corresponding to ANXA9 and SLC27A3 
      respectively were isolated, and 14 and 6 single nucleotide polymorphisms (SNPs) 
      respectively were found in each gene. ANXA9, SLC27A3, CGN and ACP6 were localized 
      to chromosome 1 between INRA006 and AE57 by linkage mapping using the 
      International Mapping Flock. Across-family analyses of a daughter design 
      comprising 13 sire families revealed significant sire and SLC27A3 
      genotype-nested-within-sire effects for FC. Within-family analyses indicated 
      significant regression coefficients for FC in four of six heterozygous sires. 
      These results could reflect the existence of a QTL for FC linked to SLC27A3 in 
      sheep.
FAU - Calvo, J H
AU  - Calvo JH
AD  - Unidad de Tecnologia en Produccion Animal, CITA-Gobierno de Aragon, Zaragoza, 
      Spain. jhcalvo@aragon.es
FAU - Martinez-Royo, A
AU  - Martinez-Royo A
FAU - Beattie, A E
AU  - Beattie AE
FAU - Dodds, K G
AU  - Dodds KG
FAU - Marcos-Carcavilla, A
AU  - Marcos-Carcavilla A
FAU - Serrano, M
AU  - Serrano M
LA  - eng
PT  - Journal Article
PL  - England
TA  - Anim Genet
JT  - Animal genetics
JID - 8605704
SB  - IM
MH  - Animals
MH  - *Chromosome Mapping
MH  - *Chromosomes, Mammalian
MH  - Genes
MH  - Genotype
MH  - *Milk/classification
MH  - Polymorphism, Single Nucleotide
MH  - *Quantitative Trait Loci
MH  - Regression Analysis
MH  - Sequence Homology, Amino Acid
MH  - Sheep/classification/*genetics
EDAT- 2006/06/01 09:00
MHDA- 2006/08/03 09:00
CRDT- 2006/06/01 09:00
PHST- 2006/06/01 09:00 [pubmed]
PHST- 2006/08/03 09:00 [medline]
PHST- 2006/06/01 09:00 [entrez]
AID - AGE1412 [pii]
AID - 10.1111/j.1365-2052.2006.01412.x [doi]
PST - ppublish
SO  - Anim Genet. 2006 Jun;37(3):205-10. doi: 10.1111/j.1365-2052.2006.01412.x.