PMID- 16736124
OWN - NLM
STAT- MEDLINE
DCOM- 20070316
LR  - 20220419
IS  - 0770-3198 (Print)
IS  - 0770-3198 (Linking)
VI  - 26
IP  - 1
DP  - 2007 Jan
TI  - Immunoglobulin E: a new diagnostic clue for Behcet's disease? IgE and Behcet's 
      disease.
PG  - 81-3
AB  - Behcet's disease (BD) is a multisystemic inflammatory disorder of unknown 
      etiology. Hyperimmunoglobulinemia has been demonstrated in BD; however, its 
      clinical importance has not yet been discovered. In a few reports, an association 
      between BD and plasma immunoglobulin E (IgE) has been noted. In this study, we 
      had three objectives: (1) to investigate plasma levels of IgE and their 
      association with levels of acute phase reactants, (2) to determine whether 
      treatment has any effect upon IgE levels, and (3) to assess whether higher serum 
      levels of IgE provide a clue for the diagnosis of BD. Fifty-two patients with BD, 
      without any accompanying disease or condition that might lead to a rise in IgE, 
      were compared with 51 age-matched healthy controls. Plasma levels of IgE, IgA, 
      IgG, and IgM were analyzed by means of nephelometric analysis. Results showed 
      that among the 52 patients, 23 (44%) had IgE levels that were higher than the 
      upper limits of normal. IgE was not correlated with age, erythrocyte 
      sedimentation rate, or C-reactive protein (p=0.59, p=0.57, and p=0.757, 
      respectively). These relationships remained nonsignificant when multiple 
      regression analysis was performed, with R (2) of 0.187 and p=0.057. Moreover, 
      treatment of patients with elevated IgE did not produce any predictable IgE 
      response. We conclude that Behcet's patients commonly exhibit elevated plasma IgE 
      levels. However, elevated IgE levels are not correlated with levels of acute 
      phase reactants or disease activity. We suggest that IgE levels might be an 
      independent diagnostic clue in Behcet's patients.
FAU - Onat, Ahmet Mesut
AU  - Onat AM
AD  - Department of Rheumatology, School of Medicine, Gaziantep University, Gaziantep, 
      Turkey. mesutonat@yahoo.com
FAU - Buyukhatipoglu, Hakan
AU  - Buyukhatipoglu H
FAU - Yilmaz, Mehmet
AU  - Yilmaz M
FAU - Geyik, Ramazan
AU  - Geyik R
FAU - Celik, Ahmet
AU  - Celik A
FAU - Ozturk, Mehmet Akif
AU  - Ozturk MA
LA  - eng
PT  - Journal Article
DEP - 20060531
PL  - Germany
TA  - Clin Rheumatol
JT  - Clinical rheumatology
JID - 8211469
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Behcet Syndrome/diagnosis/*immunology
MH  - C-Reactive Protein/metabolism
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Male
EDAT- 2006/06/01 09:00
MHDA- 2007/03/17 09:00
CRDT- 2006/06/01 09:00
PHST- 2006/04/19 00:00 [received]
PHST- 2006/05/01 00:00 [accepted]
PHST- 2006/04/30 00:00 [revised]
PHST- 2006/06/01 09:00 [pubmed]
PHST- 2007/03/17 09:00 [medline]
PHST- 2006/06/01 09:00 [entrez]
AID - 10.1007/s10067-006-0335-x [doi]
PST - ppublish
SO  - Clin Rheumatol. 2007 Jan;26(1):81-3. doi: 10.1007/s10067-006-0335-x. Epub 2006 
      May 31.