PMID- 16737793
OWN - NLM
STAT- MEDLINE
DCOM- 20070719
LR  - 20210104
IS  - 0739-7240 (Print)
IS  - 0739-7240 (Linking)
VI  - 33
IP  - 1
DP  - 2007 Jul
TI  - Increased food intake stimulates GnRH-I, glycoprotein hormone alpha-subunit and 
      follistatin mRNAs, and ovarian follicular numbers in laying broiler breeder hens.
PG  - 62-76
AB  - The aim of this study, in 36 week-old laying broiler breeder hens, was to 
      establish the effects on reproductive neuroendocrine gene expression of 
      reinstating ad libitum food intake after moderate food restriction from 2 weeks 
      of age. Seven days of ad libitum feeding increased the number of large 
      pre-ovulatory ovarian follicles and gonadotropin releasing hormone-I (GnRH-I), 
      glycoprotein hormone alpha-subunit and follistatin mRNAs. Plasma luteinizing 
      hormone (LH) was also increased while plasma follicle-stimulating hormone (FSH) 
      was reduced. There were no associated changes in gonadotropin inhibitory hormone 
      (GnIH), LHbeta or FSHbeta mRNAs. The mechanism underlying the increased 
      expression of alpha-subunit and follistatin mRNAs was investigated in vitro by 
      incubating pituitary fragments with pulses of GnRH-I. This treatment increased 
      alpha-subunit and follistatin mRNAs but did not affect gonadotropin beta-subunit 
      mRNAs. It is concluded that lifting food restriction in laying hens increases 
      GnRH-I gene transcription or mRNA stability which may be a consequence, or cause 
      of increased GnRH-I release. This, in turn, increases glycoprotein hormone 
      alpha-subunit and follistatin mRNAs, resulting in increased plasma LH and 
      decreased plasma FSH, respectively.
FAU - Ciccone, N A
AU  - Ciccone NA
AD  - Division of Genetics and Genomics, Roslin Institute, Roslin, Midlothian EH25 9PS, 
      United Kingdom.
FAU - Dunn, I C
AU  - Dunn IC
FAU - Sharp, P J
AU  - Sharp PJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060511
PL  - United States
TA  - Domest Anim Endocrinol
JT  - Domestic animal endocrinology
JID - 8505191
RN  - 0 (Follistatin)
RN  - 0 (Glycoprotein Hormones, alpha Subunit)
RN  - 0 (Glycoproteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (gonadotropin inhibitor)
RN  - 33515-09-2 (Gonadotropin-Releasing Hormone)
RN  - 9002-67-9 (Luteinizing Hormone)
RN  - 9002-68-0 (Follicle Stimulating Hormone)
SB  - IM
MH  - Animals
MH  - Chickens/genetics/metabolism/*physiology
MH  - Eating/*physiology
MH  - Female
MH  - Follicle Stimulating Hormone/blood
MH  - Follistatin/*biosynthesis/genetics
MH  - Glycoprotein Hormones, alpha Subunit/*biosynthesis/genetics
MH  - Glycoproteins/genetics/physiology
MH  - Gonadotropin-Releasing Hormone/*biosynthesis/genetics
MH  - Luteinizing Hormone/blood
MH  - Male
MH  - Ovarian Follicle/metabolism/*physiology
MH  - Pituitary Gland/physiology
MH  - RNA, Messenger/biosynthesis/genetics
MH  - Random Allocation
MH  - Reverse Transcriptase Polymerase Chain Reaction/veterinary
EDAT- 2006/06/02 09:00
MHDA- 2007/07/20 09:00
CRDT- 2006/06/02 09:00
PHST- 2006/04/18 00:00 [received]
PHST- 2006/04/25 00:00 [accepted]
PHST- 2006/06/02 09:00 [pubmed]
PHST- 2007/07/20 09:00 [medline]
PHST- 2006/06/02 09:00 [entrez]
AID - S0739-7240(06)00062-2 [pii]
AID - 10.1016/j.domaniend.2006.04.008 [doi]
PST - ppublish
SO  - Domest Anim Endocrinol. 2007 Jul;33(1):62-76. doi: 
      10.1016/j.domaniend.2006.04.008. Epub 2006 May 11.