PMID- 16737879
OWN - NLM
STAT- MEDLINE
DCOM- 20060622
LR  - 20061115
IS  - 0022-3476 (Print)
IS  - 0022-3476 (Linking)
VI  - 148
IP  - 5
DP  - 2006 May
TI  - HLA typing associated with hepatitis B E antigen seroconversion in children with 
      chronic hepatitis B virus infection: a long-term prospective sibling cohort study 
      in Taiwan.
PG  - 647-651
AB  - OBJECTIVE: To conduct a prospective cohort study to clarify the relationship 
      between human leukocyte antigen (HLA) polymorphisms and the seroconversion of 
      hepatitis B e antigen (HBeAg). STUDY DESIGN: In the prospective cohort study, 81 
      HBeAg-positive children with chronic hepatitis B virus (HBV) infection from 40 
      unrelated families were recruited and followed-up regularly for a mean period of 
      17.70 +/- 3.23 years. The association between HLA antigen and the age at HBeAg 
      seroconversion was analyzed using Cox regression model with shared frailties 
      under left truncation and right censorship. RESULTS: HLA-B61 and HLA-DQB1*0503 
      antigens predicted a higher HBeAg seroconversion rate (relative incidence = 6.17 
      and 3.22, P = .024 and .017, respectively). Within-family frailty in our sibling 
      cohort study demonstrated a negligible or a low degree of within-family 
      correlation with spontaneous HBeAg seroconversion in each HLA antigen. 
      CONCLUSIONS: HLA class I antigen B61 and class II antigen DQB1*0503 are 
      associated with earlier HBeAg seroconversion in Taiwanese children with chronic 
      HBV infection.
FAU - Wu, Jia-Feng
AU  - Wu JF
AD  - Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan.
FAU - Chen, Chen-Hsin
AU  - Chen CH
FAU - Hsieh, Rhong-Phong
AU  - Hsieh RP
FAU - Shih, Hsiang-Hung
AU  - Shih HH
FAU - Chen, Yi-Hau
AU  - Chen YH
FAU - Li, Chi-Rong
AU  - Li CR
FAU - Chiang, Chih-Yao
AU  - Chiang CY
FAU - Shau, Wen-Yi
AU  - Shau WY
FAU - Ni, Yen-Hsuan
AU  - Ni YH
FAU - Chen, Huey-Ling
AU  - Chen HL
FAU - Hsu, Hong-Yuan
AU  - Hsu HY
FAU - Chang, Mei-Hwei
AU  - Chang MH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Pediatr
JT  - The Journal of pediatrics
JID - 0375410
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (Hepatitis B e Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Female
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DR Antigens/*genetics
MH  - Hepatitis B e Antigens/*blood
MH  - Hepatitis B, Chronic/*blood/*genetics
MH  - Histocompatibility Antigens Class I/*blood
MH  - Histocompatibility Testing
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Polymorphism, Genetic/genetics
MH  - Siblings
MH  - Taiwan
EDAT- 2006/06/02 09:00
MHDA- 2006/06/23 09:00
CRDT- 2006/06/02 09:00
PHST- 2005/07/13 00:00 [received]
PHST- 2005/10/06 00:00 [revised]
PHST- 2005/12/08 00:00 [accepted]
PHST- 2006/06/02 09:00 [pubmed]
PHST- 2006/06/23 09:00 [medline]
PHST- 2006/06/02 09:00 [entrez]
AID - S0022-3476(05)01186-8 [pii]
AID - 10.1016/j.jpeds.2005.12.025 [doi]
PST - ppublish
SO  - J Pediatr. 2006 May;148(5):647-651. doi: 10.1016/j.jpeds.2005.12.025.