PMID- 16737918
OWN - NLM
STAT- MEDLINE
DCOM- 20060724
LR  - 20091119
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 167
IP  - 2
DP  - 2006 Jun
TI  - Inversions of chromosomes 2 and 6 in mantle cell lymphoma. Cytogenetic, FISH, and 
      molecular studies.
PG  - 164-7
AB  - Inversions are infrequent events in hematological malignancies. We here report 
      the cytogenetic, fluorescence in situ hybridization (FISH), and molecular studies 
      of 2 patients diagnosed with mantle cell lymphoma (MCL) that showed inversions of 
      chromosomes 2 and 6 as part of complex karyotypes. Both patients showed a 
      cytogenetically identical inv(6)(p23q11) detected as a secondary aberration. In 
      addition, both patients had a derivative chromosome 2 which originated by partial 
      deletion of the short arm and a pericentric inversion with different breakpoints 
      on the long arm: der(2)del(2)(p21)inv(2)(p21q11) and 
      der(2)del(2)(p21)inv(2)(p21q13), respectively. The presence of t(11;14)(q13;q32) 
      was confirmed by interphase FISH and by molecular study. Residual normal cells 
      were found in both cases. The patients showed a different clinical evolution with 
      a poor outcome for one case and a favorable course of the disease for the other 
      one. The review of the literature in MCL showed a total of 9 inversions affecting 
      different chromosomes. Considering that inversions are very infrequent events in 
      MCL, our findings could be important for detecting genes potentially involved in 
      development and/or progression of this aggressive non-Hodgkin lymphoma subtype.
FAU - Pedrazzini, Estela
AU  - Pedrazzini E
AD  - Departamento de Genetica, Instituto de Investigaciones Hematologicas Mariano R. 
      Castex, Academia Nacional de Medicina, Pacheco de Melo 3081-1425, Buenos Aires, 
      Argentina.
FAU - Cerretini, Roxana
AU  - Cerretini R
FAU - Noriega, Maria Fernanda
AU  - Noriega MF
FAU - Narbaitz, Marina
AU  - Narbaitz M
FAU - Palacios, Maria Fernanda
AU  - Palacios MF
FAU - Negri, Pedro
AU  - Negri P
FAU - Bengio, Raquel
AU  - Bengio R
FAU - Slavutsky, Irma
AU  - Slavutsky I
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Chromosome Inversion
MH  - *Chromosomes, Human, Pair 2/ultrastructure
MH  - *Chromosomes, Human, Pair 6/ultrastructure
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Lymphoma, Mantle-Cell/diagnosis/*genetics
MH  - Male
MH  - Polymerase Chain Reaction
EDAT- 2006/06/02 09:00
MHDA- 2006/07/25 09:00
CRDT- 2006/06/02 09:00
PHST- 2005/09/29 00:00 [received]
PHST- 2005/11/15 00:00 [revised]
PHST- 2005/12/02 00:00 [accepted]
PHST- 2006/06/02 09:00 [pubmed]
PHST- 2006/07/25 09:00 [medline]
PHST- 2006/06/02 09:00 [entrez]
AID - S0165-4608(05)00737-5 [pii]
AID - 10.1016/j.cancergencyto.2005.12.004 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2006 Jun;167(2):164-7. doi: 
      10.1016/j.cancergencyto.2005.12.004.