PMID- 16738669
OWN - NLM
STAT- MEDLINE
DCOM- 20060914
LR  - 20161122
IS  - 1466-4879 (Print)
IS  - 1466-4879 (Linking)
VI  - 7
IP  - 5
DP  - 2006 Jul
TI  - Incremental expression of Tlr4 correlates with mouse resistance to Salmonella 
      infection and fine regulation of relevant immune genes.
PG  - 372-83
AB  - The mouse response to Salmonella Typhimurium infection is partly controlled 
      through detection of the bacterium lipopolysaccharide by the host pattern 
      recognition receptor, Toll-like receptor 4 (Tlr4). Mice deficient in Tlr4 
      signaling are extremely susceptible to Salmonella infection with a 1,000-fold 
      reduction in LD(50). In a previous study, we showed, using transgenic mice 
      carrying one, three, six and >30 copies of Tlr4, that the level of expression of 
      this gene influences the outcome of Salmonella infection, with a plateau effect 
      starting at three copies. In the present study, we further investigate the impact 
      of Tlr4 during Salmonella infection in mice expressing Tlr4 at slightly 
      sub-normal, normal and slightly supra-normal levels by comparing host responses 
      in mice carrying one, two and three copies of Tlr4 on the same genetic 
      background. We describe in detail the in vivo host response to pathogenic 
      Salmonella and show for the first time, in this narrow range of Tlr4 expression, 
      an incremental protective effect against Salmonella due to improved control of 
      bacterial growth in target organs and increased expression of important immune 
      response genes in the spleen.
FAU - Roy, M-F
AU  - Roy MF
AD  - Department of Human Genetics, McGill University Health Center, Montreal, Quebec, 
      Canada.
FAU - Lariviere, L
AU  - Lariviere L
FAU - Wilkinson, R
AU  - Wilkinson R
FAU - Tam, M
AU  - Tam M
FAU - Stevenson, M M
AU  - Stevenson MM
FAU - Malo, D
AU  - Malo D
LA  - eng
GR  - 12038-3/Canadian Institutes of Health Research/Canada
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060601
PL  - England
TA  - Genes Immun
JT  - Genes and immunity
JID - 100953417
RN  - 0 (RNA, Messenger)
RN  - 0 (Toll-Like Receptor 4)
SB  - IM
EIN - Genes Immun. 2006 Jul;7(5):437
MH  - Alleles
MH  - Animals
MH  - Gene Dosage
MH  - Gene Expression Regulation/*immunology
MH  - Mice
MH  - Mice, Transgenic
MH  - RNA, Messenger/analysis
MH  - Salmonella Infections, Animal/*genetics/*immunology/microbiology/mortality
MH  - Toll-Like Receptor 4/*genetics/*metabolism
MH  - Transgenes
EDAT- 2006/06/02 09:00
MHDA- 2006/09/15 09:00
CRDT- 2006/06/02 09:00
PHST- 2006/06/02 09:00 [pubmed]
PHST- 2006/09/15 09:00 [medline]
PHST- 2006/06/02 09:00 [entrez]
AID - 6364309 [pii]
AID - 10.1038/sj.gene.6364309 [doi]
PST - ppublish
SO  - Genes Immun. 2006 Jul;7(5):372-83. doi: 10.1038/sj.gene.6364309. Epub 2006 Jun 1.