PMID- 16738805
OWN - NLM
STAT- MEDLINE
DCOM- 20061214
LR  - 20220408
IS  - 1360-8185 (Print)
IS  - 1360-8185 (Linking)
VI  - 11
IP  - 9
DP  - 2006 Sep
TI  - General anesthesia activates BDNF-dependent neuroapoptosis in the developing rat 
      brain.
PG  - 1603-15
AB  - Brain-derived neurotrophic factor (BDNF) is important in supporting neuronal 
      development. BDNF imbalance due to excessive neuronal inhibition can result in 
      the apoptotic degeneration of developing neurons. Since general anesthetics cause 
      profound depression of neuronal activity and are known to induce widespread 
      degeneration in the developing brain, we studied their potential to activate 
      BDNF-mediated developmental neuroapoptosis. When P7 rats (at the peak of brain 
      development) were exposed to a commonly-used and highly pro-apoptotic anesthesia 
      protocol (midazolam, isoflurane, nitrous oxide) for a period of 2, 4 or 6 h, we 
      found that anesthesia modulates the key steps in BDNF-activated apoptotic cascade 
      in two of the most vulnerable brain regions--cerebral cortex and thalamus in 
      time-dependent fashion by activating both Trk-dependent (in thalamus) and 
      Trk-independent p75NTR dependent (in cerebral cortex) neurotrophic pathways. 
      beta-estradiol, a sex hormone that upregulates the protein levels of the 
      activated Akt, protects against anesthesia-induced neuroapoptosis.
FAU - Lu, Lucy X
AU  - Lu LX
AD  - Department of Anasthesiology, University of Virginia Health System, P.O. Box 
      800710, Charlottesville, 22908, USA.
FAU - Yon, Jun-Heum
AU  - Yon JH
FAU - Carter, Lisa B
AU  - Carter LB
FAU - Jevtovic-Todorovic, Vesna
AU  - Jevtovic-Todorovic V
LA  - eng
GR  - AG 11355/AG/NIA NIH HHS/United States
GR  - HD 44517/HD/NICHD NIH HHS/United States
GR  - K08-DA00406/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Apoptosis
JT  - Apoptosis : an international journal on programmed cell death
JID - 9712129
RN  - 0 (Anesthetics)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Oncogene Proteins)
RN  - 0 (oncogene protein trk)
RN  - 4TI98Z838E (Estradiol)
RN  - EC 2.7.11.1 (Oncogene Protein v-akt)
SB  - IM
MH  - Anesthesia, General/*adverse effects
MH  - Anesthetics/adverse effects/pharmacology
MH  - Animals
MH  - Apoptosis/*drug effects/physiology
MH  - Brain/drug effects/*growth & development
MH  - Brain-Derived Neurotrophic Factor/metabolism/*physiology
MH  - Cerebral Cortex/drug effects/growth & development
MH  - Down-Regulation/drug effects
MH  - Estradiol/pharmacology
MH  - Models, Biological
MH  - Nerve Degeneration/chemically induced
MH  - Neurons/*drug effects
MH  - Oncogene Protein v-akt/metabolism
MH  - Oncogene Proteins/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Respiratory Insufficiency/chemically induced
MH  - Signal Transduction/drug effects
MH  - Thalamus/drug effects/growth & development
EDAT- 2006/06/02 09:00
MHDA- 2006/12/15 09:00
CRDT- 2006/06/02 09:00
PHST- 2006/06/02 09:00 [pubmed]
PHST- 2006/12/15 09:00 [medline]
PHST- 2006/06/02 09:00 [entrez]
AID - 10.1007/s10495-006-8762-3 [doi]
PST - ppublish
SO  - Apoptosis. 2006 Sep;11(9):1603-15. doi: 10.1007/s10495-006-8762-3.