PMID- 16738956
OWN - NLM
STAT- MEDLINE
DCOM- 20060921
LR  - 20181113
IS  - 0344-4325 (Print)
IS  - 0344-4325 (Linking)
VI  - 27
IP  - 4
DP  - 2006 Jun
TI  - Biologics in the prevention and treatment of graft rejection.
PG  - 457-76
AB  - Biologics are used in solid organ allografting and hematopoietic stem cell 
      transplantation (HSCT) for the induction and maintenance of immunosuppression. In 
      solid organ transplantation, antibodies targeting T cells are part of induction 
      protocols administered for initiation of immunosuppression during organ transfer 
      and during sustained post transplant periods for prevention of graft rejection. 
      Several clinical trials in renal allografting provide data for the efficacy and 
      safety of biologics in this clinical setting. Application of biologics also 
      allows the reduction of calcineurin inhibitors, thereby reducing toxicity and 
      improving long-term graft function. In acute rejection periods, anti T cell 
      antibodies are established in steroid-resistant cases. Strategies interfering 
      with the activity of soluble cytokines are less frequently applied for solid 
      organ transplantation. In HSCT, T cell directed antibodies as part of 
      conditioning protocols improve engraftment and reduce the incidence of 
      detrimental graft vs host disease (GvHD). In acute GvHD, both antibodies 
      targeting T cells and cytokines like TNF-alpha are established therapeutics for 
      remission induction.
FAU - Marks, Reinhard
AU  - Marks R
AD  - Department of Hematology/Oncology, University Hospital Freiburg, Hugstetter 
      Street 55, Freiburg 79106, Germany. juergen.finke@uniklinik-freiburg.de
FAU - Finke, Jurgen
AU  - Finke J
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20060509
PL  - Germany
TA  - Springer Semin Immunopathol
JT  - Springer seminars in immunopathology
JID - 7910384
RN  - 0 (Antibodies)
SB  - IM
MH  - Animals
MH  - Antibodies/immunology/*therapeutic use
MH  - Graft Rejection/*immunology/*prevention & control
MH  - Hematopoietic Stem Cell Transplantation/methods
MH  - Humans
MH  - Immunotherapy/methods
MH  - Kidney Transplantation/immunology
MH  - Mice
MH  - Rabbits
MH  - T-Lymphocytes/immunology
RF  - 94
EDAT- 2006/06/02 09:00
MHDA- 2006/09/22 09:00
CRDT- 2006/06/02 09:00
PHST- 2006/02/23 00:00 [received]
PHST- 2006/03/21 00:00 [accepted]
PHST- 2006/06/02 09:00 [pubmed]
PHST- 2006/09/22 09:00 [medline]
PHST- 2006/06/02 09:00 [entrez]
AID - 10.1007/s00281-006-0014-7 [doi]
PST - ppublish
SO  - Springer Semin Immunopathol. 2006 Jun;27(4):457-76. doi: 
      10.1007/s00281-006-0014-7. Epub 2006 May 9.