PMID- 16739380
OWN - NLM
STAT- MEDLINE
DCOM- 20110411
LR  - 20140625
VI  - 20
IP  - 6
DP  - 2006 Mar
TI  - [Detection of cyclin E in lymph node metastases of laryngeal squamous cell 
      carcinomas by laser scanning confocal microscopy].
PG  - 262-3, 267
AB  - OBJECTIVE: To study the expression of Cyclin E proteins in carcinogenesis and 
      development of the metastasis of laryngeal squamous cell carcinomas (LSCC). 
      METHOD: The expression of Cyclin E protein were detected by laser scanning 
      confocal microscopy (LSCM) and multiparameter flow cytometry (FCM) after 
      immunofluorescence staining method in twenty-one surgically resected primary LSCC 
      (7 LSCC with cervical lymph node metastasis, 14 LSCC without cervical lymph node 
      metastasis). RESULT: The fluorescence intensity was 78.12 +/- 6.54 in LSCC with 
      cervical lymph node metastasis and 74.93 +/- 8. 82 in LSCC without cervical lymph 
      node metastasis (P > 0. 05); The fluorescence intensity in cervical lymph node 
      metastasis was 93.65 +/- 7.48, it's more higher than that in cervical lymph node 
      negative metastasis (P < 0.01) and both LSCC with cervical lymph node metastasis 
      and without cervical lymph node metastasis (P < 0.05). CONCLUSION: It is 
      suggested that Cyclin E proteins may play an important role in the carcinogenesis 
      and development of the lymph node metastases of LSCC. Detection of Cyclin E maybe 
      becomes an indication to evaluating the lymph node metastases of LSCC.
FAU - Zhang, Xiaowen
AU  - Zhang X
AD  - Department of Otolaryngology-Head and Neck Surgery, the Third Affiliated Hospital 
      of Sun Yat-sen University, Guangzhou, 510630, China.
FAU - Kong, Weijia
AU  - Kong W
FAU - Hu, Bin
AU  - Hu B
FAU - Wang, Zhenlin
AU  - Wang Z
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Ke Za Zhi
JT  - Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
JID - 9426080
RN  - 0 (Cyclin E)
SB  - IM
MH  - Carcinoma, Squamous Cell/*metabolism/pathology
MH  - Cyclin E/*metabolism
MH  - Humans
MH  - Laryngeal Neoplasms/*metabolism/pathology
MH  - Lymph Nodes/*metabolism/pathology
MH  - Lymphatic Metastasis
MH  - Microscopy, Confocal
MH  - Neoplasm Staging
EDAT- 2006/06/03 09:00
MHDA- 2011/04/13 06:00
CRDT- 2006/06/03 09:00
PHST- 2006/06/03 09:00 [pubmed]
PHST- 2011/04/13 06:00 [medline]
PHST- 2006/06/03 09:00 [entrez]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2006 Mar;20(6):262-3, 267.