PMID- 16740240
OWN - NLM
STAT- MEDLINE
DCOM- 20061012
LR  - 20190917
IS  - 0300-2896 (Print)
IS  - 0300-2896 (Linking)
VI  - 42
IP  - 5
DP  - 2006 May
TI  - [Anti-immunoglobulin E, a monoclonal antibody to treat respiratory disorders].
PG  - 241-5
AB  - Omalizumab is a monoclonal antibody that interrupts allergic 
      reaction--irrespective of the nature of the allergen--by blocking free 
      immunoglobulin E (IgE). The IgE is thus prevented from attaching to cell 
      receptors and setting in motion an allergic cascade of inflammatory mediators. 
      Other interesting biological effects of omalizumab are that it downregulates IgE 
      receptor expression on cell membranes and reduces bronchial eosinophilic 
      infiltration. Clinical trials have demonstrated omalizumab's efficacy and safety 
      in treating most allergic disorders. However, given its high cost, omalizumab is 
      generally reserved for more severe cases of asthma and for asthma that responds 
      poorly to conventional treatments.
FAU - Cabrera-Navarro, P
AU  - Cabrera-Navarro P
AD  - Servicio de Neumologia, Hospital Universitario Dr. Negrin, Las Palmas de Gran 
      Canaria, Las Palmas, Espana. pcabnav@gobiernodecanarias.org
LA  - spa
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Antiinmunoglobulina E, un anticuerpo monoclonal, en el tratamiento de las 
      enfermedades respiratorias.
PL  - Spain
TA  - Arch Bronconeumol
JT  - Archivos de bronconeumologia
JID - 0354720
RN  - 0 (Antibodies, Anti-Idiotypic)
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Antibodies, Monoclonal, Humanized)
RN  - 0 (anti-IgE antibodies)
RN  - 2P471X1Z11 (Omalizumab)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Antibodies, Anti-Idiotypic/*therapeutic use
MH  - Antibodies, Monoclonal/*therapeutic use
MH  - Antibodies, Monoclonal, Humanized
MH  - Asthma/*drug therapy/immunology
MH  - Clinical Trials as Topic
MH  - Humans
MH  - *Immunoglobulin E
MH  - Omalizumab
RF  - 41
EDAT- 2006/06/03 09:00
MHDA- 2006/10/13 09:00
CRDT- 2006/06/03 09:00
PHST- 2006/06/03 09:00 [pubmed]
PHST- 2006/10/13 09:00 [medline]
PHST- 2006/06/03 09:00 [entrez]
AID - 13088029 [pii]
AID - 10.1016/s1579-2129(06)60453-9 [doi]
PST - ppublish
SO  - Arch Bronconeumol. 2006 May;42(5):241-5. doi: 10.1016/s1579-2129(06)60453-9.