PMID- 16740681
OWN - NLM
STAT- MEDLINE
DCOM- 20070130
LR  - 20181113
IS  - 0003-4967 (Print)
IS  - 1468-2060 (Electronic)
IS  - 0003-4967 (Linking)
VI  - 66
IP  - 1
DP  - 2007 Jan
TI  - Up regulation of monocyte chemoattractant protein-1 expression in anti-citrulline 
      antibody and immunoglobulin M rheumatoid factor positive subjects precedes onset 
      of inflammatory response and development of overt rheumatoid arthritis.
PG  - 121-3
AB  - OBJECTIVE: To analyse the inflammatory mediators, including monocyte 
      chemoattractant protein-1 (MCP-1), in blood samples donated years before onset of 
      rheumatoid arthritis. Previously, it has been shown in these individuals that 
      antibodies against cyclic citrullinated peptide (anti-CCP) detectable years 
      before the onset of symptoms have a high predictive value for development of 
      rheumatoid arthritis. METHODS: A nested case-control study was performed: 
      patients with rheumatoid arthritis were identified from among blood donors 
      antedating onset by a median of three years (pre-patients, n = 92); four matched 
      controls were selected randomly for each pre-patient. Plasma were analysed for 
      secretory phospholipase A2 (sPLA2) and MCP-1 using ELISA, for high-sensitivity C 
      reactive protein (hsCRP) using the chemiluminescence method and for interleukin-6 
      using a sensitive bioassay. RESULTS: When the results were stratified for the 
      presence of anti-CCP antibodies and immunoglobulin M-rheumatoid factor (IgM-RF), 
      only MCP-1 levels were found to be significantly raised in patients with anti-CCP 
      and IgM-RF compared with controls. CONCLUSION: Levels of MCP-1 were significantly 
      increased in the plasma of patients having anti-CCP antibodies or IgM-RF and who 
      later developed rheumatoid arthritis. These findings indicate up regulation of 
      chemotactic activity for leucocytes before the development of rheumatoid 
      arthritis.
FAU - Rantapaa-Dahlqvist, S
AU  - Rantapaa-Dahlqvist S
AD  - Department of Rheumatology, University Hospital, SE-901 85 Umea, Sweden. 
      Solbritt.Rantapaa.Dahlqvist@medicin.umu.se
FAU - Boman, K
AU  - Boman K
FAU - Tarkowski, A
AU  - Tarkowski A
FAU - Hallmans, G
AU  - Hallmans G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060601
PL  - England
TA  - Ann Rheum Dis
JT  - Annals of the rheumatic diseases
JID - 0372355
RN  - 0 (Autoantibodies)
RN  - 0 (Biomarkers)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Immunoglobulin M)
RN  - 29VT07BGDA (Citrulline)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - 9009-79-4 (Rheumatoid Factor)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Arthritis, Rheumatoid/*blood
MH  - Autoantibodies/*blood
MH  - Biomarkers/blood
MH  - Blood Donors
MH  - C-Reactive Protein/analysis
MH  - Case-Control Studies
MH  - Chemokine CCL2/*blood
MH  - Chi-Square Distribution
MH  - Citrulline/*immunology
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Immunoglobulin M/blood
MH  - Male
MH  - Middle Aged
MH  - Rheumatoid Factor/blood
MH  - Severity of Illness Index
MH  - Time Factors
MH  - *Up-Regulation
PMC - PMC1798414
COIS- Competing interests: None declared.
EDAT- 2006/06/03 09:00
MHDA- 2007/01/31 09:00
PMCR- 2010/01/01
CRDT- 2006/06/03 09:00
PHST- 2006/06/03 09:00 [pubmed]
PHST- 2007/01/31 09:00 [medline]
PHST- 2006/06/03 09:00 [entrez]
PHST- 2010/01/01 00:00 [pmc-release]
AID - ard.2006.057331 [pii]
AID - ar57331 [pii]
AID - 10.1136/ard.2006.057331 [doi]
PST - ppublish
SO  - Ann Rheum Dis. 2007 Jan;66(1):121-3. doi: 10.1136/ard.2006.057331. Epub 2006 Jun 
      1.