PMID- 16741011
OWN - NLM
STAT- MEDLINE
DCOM- 20060705
LR  - 20061115
IS  - 1535-3702 (Print)
IS  - 1535-3699 (Linking)
VI  - 231
IP  - 6
DP  - 2006 Jun
TI  - Short-term effect of rate control on plasma endothelin levels of patients with 
      tachyarrhythmias.
PG  - 852-6
AB  - Radiofrequency catheter ablation or modification of the atrio-ventricular 
      junction is an effective therapy of drug refractory supraventricular 
      tachyarrhythmias (ST). Higher endothelin (ET) levels were observed during 
      nonsustained STs. We aimed to examine the effect of sustained STs and the applied 
      rate-control therapy on plasma ET levels. Twenty-two patients (12 men; mean age, 
      64.4 +/- 13.2 years; ejection fraction, 41.8 +/- 11.2%; New York Heart 
      Association (NYHA) class I: 3 cases, NYHA II: 11 cases, and NYHA III: 8 cases) 
      suffering of atrial fibrillation (n = 11), atrial flutter (n = 7), atrial 
      paroxysmal tachycardia (n = 3), or sinus tachycardia (n = 1) were studied, having 
      coronary artery disease (n = 8), dilative cardiomyopathy (n = 5), or no 
      underlying diseases (n = 9). All groups went under catheter ablation (same 
      protocol, duration: 35 +/- 10.3 mins; rate before ablation, 100-170/min in every 
      case; after ablation, 70-80/min in Groups I and II and 70-90/min in Group III). A 
      pacemaker (PM) was implanted 2 months before ablation in Group I (n = 9) and 
      during ablation in Group II (n = 7). No PM was implanted in Group III (n = 6). A 
      control group (n = 13; 7 men; mean age, 66.15 +/- 6.7 years) with sinus rhythm 
      got a PM without ST and ablation. Blood samples were collected from the cubital 
      vein immediately before (control), and 5 mins and 24 hrs after ablation. Plasma 
      ET-1 and big ET-1 levels were measured after immunoprecipitation with Western 
      blot analysis. There were no differences between plasma ET-1 levels in the ST 
      groups and the control group (Groups I, II, and III vs. control group: 0.66 +/- 
      0.04 fmol/ml, 0.93 +/- 0.12 fmol/ml, and 0.68 +/- 0.05 fmol/ml vs. 0.50 +/- 0.05 
      fmol/ml, respectively; P < 0.05). Comparing the control, 5-min, and 24-hr 
      samples, ET-1 levels decreased significantly after supraventricular tachycardia 
      ablation in Groups I and III (control vs. Group I, 5 mins and 24 hrs: 0.66 +/- 
      0.04 fmol/ml vs. 0.50 +/- 0.04 fmol/ml and 0.29 +/- 0.05 fmol/ml; control vs. 
      Group III, 24 hrs: 0.68 +/- 0.05 vs. 0.34 +/- 0.05 fmol/ml; P < 0.05). No plasma 
      big ET-1 changes were measured in any of the groups. The rapid decrease of ET 
      levels after catheter ablation suggests that a high ventricular rate can be a 
      trigger of ET production. PM implantation procedure seems to interfere with the 
      ET decrease in ST patients.
FAU - Dezsi, Csaba A
AU  - Dezsi CA
AD  - Petz Aladar County Teaching Hospital, Gyor, Hungary.
FAU - Szucs, Andrea
AU  - Szucs A
FAU - Szucs, Gabor
AU  - Szucs G
FAU - Roka, Attila
AU  - Roka A
FAU - Kiss, Orsolya
AU  - Kiss O
FAU - Becker, David
AU  - Becker D
FAU - Merkely, Bela
AU  - Merkely B
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Exp Biol Med (Maywood)
JT  - Experimental biology and medicine (Maywood, N.J.)
JID - 100973463
RN  - 0 (Endothelins)
SB  - IM
MH  - Aged
MH  - Atrial Fibrillation/therapy
MH  - Case-Control Studies
MH  - Catheter Ablation
MH  - Endothelins/*blood
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pacemaker, Artificial
MH  - Tachycardia, Supraventricular/*physiopathology/surgery
MH  - Time Factors
EDAT- 2006/06/03 09:00
MHDA- 2006/07/06 09:00
CRDT- 2006/06/03 09:00
PHST- 2006/06/03 09:00 [pubmed]
PHST- 2006/07/06 09:00 [medline]
PHST- 2006/06/03 09:00 [entrez]
AID - 231/6/852 [pii]
PST - ppublish
SO  - Exp Biol Med (Maywood). 2006 Jun;231(6):852-6.