PMID- 16741188
OWN - NLM
STAT- MEDLINE
DCOM- 20060718
LR  - 20221207
IS  - 1524-4628 (Electronic)
IS  - 0039-2499 (Linking)
VI  - 37
IP  - 7
DP  - 2006 Jul
TI  - Cytokine polymorphisms associated with carotid intima-media thickness in stroke 
      patients.
PG  - 1691-6
AB  - BACKGROUND AND PURPOSE: Carotid intima-media thickness (IMT) reflects generalized 
      atherosclerosis and is predictive of future vascular events. Evidence exists that 
      carotid IMT is heritable, and genetic studies can provide clues in the 
      pathogenesis of atherosclerosis. METHODS: We recruited 470 white ischemic stroke 
      patients, measured common carotid artery (CCA) IMT, and analyzed 54 polymorphisms 
      with suspected roles in atherosclerosis. RESULTS: Among the polymorphisms tested, 
      the angiotensin-converting enzyme insertion/deletion, osteopontin (OPN) T-443C, 
      monocyte chemoattractant protein-1 (MCP-1) G-927C, and MCP-1 A-2578G 
      polymorphisms were associated with CCA-IMT in age-gender-adjusted analysis. In 
      multivariate analysis, the association between the OPN and MCP-1 polymorphisms 
      remained significant. The OPN-443C allele was associated with increased IMT in 
      the dominant model (0.053 mm for the TC and CC genotypes; P=0.001). The 
      MCP-1-927C allele was associated with increased IMT in the additive model (0.040 
      mm for each C allele; P=0.001), and the MCP-1-2578 G allele was associated with 
      decreased IMT in the recessive model (0.088 mm for the GG genotype; P=0.002). 
      CONCLUSIONS: The OPN and MCP-1 genes, coding for 2 cytokines with known roles in 
      atherosclerosis, may contribute to increased carotid IMT and warrant further 
      study.
FAU - Brenner, David
AU  - Brenner D
AD  - Department of Neurology and Stroke Centre, Bichat University Hospital, Denis 
      Diderot University and Medical School, Paris, France.
FAU - Labreuche, Julien
AU  - Labreuche J
FAU - Touboul, Pierre-Jean
AU  - Touboul PJ
FAU - Schmidt-Petersen, Klaus
AU  - Schmidt-Petersen K
FAU - Poirier, Odette
AU  - Poirier O
FAU - Perret, Claire
AU  - Perret C
FAU - Schonfelder, Jacqueline
AU  - Schonfelder J
FAU - Combadiere, Christophe
AU  - Combadiere C
FAU - Lathrop, Mark
AU  - Lathrop M
FAU - Cambien, Francois
AU  - Cambien F
FAU - Brand-Herrmann, Stefan-Martin
AU  - Brand-Herrmann SM
FAU - Amarenco, Pierre
AU  - Amarenco P
CN  - GENIC Investigators
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20060601
PL  - United States
TA  - Stroke
JT  - Stroke
JID - 0235266
RN  - 0 (Blood Proteins)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Enzymes)
RN  - 0 (SPP1 protein, human)
RN  - 0 (Sialoglycoproteins)
RN  - 106441-73-0 (Osteopontin)
RN  - EC 3.4.15.1 (Peptidyl-Dipeptidase A)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Blood Proteins/genetics
MH  - Brain Ischemia/genetics
MH  - Carotid Artery Diseases/diagnostic imaging/*genetics/pathology
MH  - Carotid Artery, Common/diagnostic imaging/*ultrastructure
MH  - Chemokine CCL2/*genetics/physiology
MH  - Enzymes/genetics
MH  - Female
MH  - France/epidemiology
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Osteopontin
MH  - Peptidyl-Dipeptidase A/genetics
MH  - Polymerase Chain Reaction
MH  - *Polymorphism, Genetic
MH  - Polymorphism, Single-Stranded Conformational
MH  - Risk Factors
MH  - Sialoglycoproteins/*genetics/physiology
MH  - Tunica Intima/diagnostic imaging/*ultrastructure
MH  - Tunica Media/diagnostic imaging/*ultrastructure
MH  - Ultrasonography
MH  - White People/genetics
EDAT- 2006/06/03 09:00
MHDA- 2006/07/19 09:00
CRDT- 2006/06/03 09:00
PHST- 2006/06/03 09:00 [pubmed]
PHST- 2006/07/19 09:00 [medline]
PHST- 2006/06/03 09:00 [entrez]
AID - 01.STR.0000226565.76113.6c [pii]
AID - 10.1161/01.STR.0000226565.76113.6c [doi]
PST - ppublish
SO  - Stroke. 2006 Jul;37(7):1691-6. doi: 10.1161/01.STR.0000226565.76113.6c. Epub 2006 
      Jun 1.