PMID- 16741292
OWN - NLM
STAT- MEDLINE
DCOM- 20061004
LR  - 20210217
IS  - 0022-2275 (Print)
IS  - 0022-2275 (Linking)
VI  - 47
IP  - 9
DP  - 2006 Sep
TI  - A systematic review and meta-analysis of the relationship between lipoprotein 
      lipase Asn291Ser variant and diseases.
PG  - 1908-14
AB  - This systematic review attempted to summarize the associations between the 
      Asn291Ser variant in the lipoprotein lipase (LPL) gene and dyslipidemia, the risk 
      of type 2 diabetes mellitus (T2DM), and coronary heart disease (CHD). In 
      addition, the relationships between the Asn291Ser variant and other metabolic 
      diseases such as obesity and high blood pressure were also investigated in this 
      systematic review. We systematically reviewed the literature by means of a 
      meta-analysis. Twenty-one articles, including 19,246 white subjects, were 
      selected for this meta-analysis. The summary standardized mean difference (SMD) 
      of plasma triglyceride (TG) for carriers compared with noncarriers of the 
      Asn291Ser variant was 3.23 (P < 0.00001). The summary SMD of plasma 
      HDL-cholsterol (HDL-C) for carriers compared with noncarriers of the Asn291Ser 
      variant was -3.42 (P < 0.0001). The summary SMD of the association of the 
      Asn291Ser variant with plasma TG increased with increasing age and weight gain. 
      Significant interactions between the LPL Asn291Ser variant and fasting glucose, 
      T2DM, and CHD were seen (P = 0.02, 0.04, and 0.01, respectively). No significant 
      interactions were seen between the LPL Asn291Ser variant and body mass index, 
      waist-hip ratio, and blood pressure (P > 0.05). This meta-analysis indicates that 
      the Asn291Ser variant in the LPL gene is a risk factor for dyslipidemia, 
      characterized by hypertriglyceridemia and low HDL-C levels. And the Asn291Ser 
      variant in the LPL gene predisposes to more severe dyslipidemia with increasing 
      age and weight gain. Also, this meta-analysis shows that the LPL Asn291Ser 
      variant is associated with CHD and T2DM.
FAU - Hu, Yaomin
AU  - Hu Y
AD  - Division of Endocrinology, Department of Internal Medicine, Renji Hospital, 
      Shanghai Jiaotong University, Shanghai 200127, China. Amin99@163.com
FAU - Liu, Wei
AU  - Liu W
FAU - Huang, Rong
AU  - Huang R
FAU - Zhang, Xiaoying
AU  - Zhang X
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
DEP - 20060601
PL  - United States
TA  - J Lipid Res
JT  - Journal of lipid research
JID - 0376606
RN  - 452VLY9402 (Serine)
RN  - 7006-34-0 (Asparagine)
RN  - EC 3.1.1.34 (Lipoprotein Lipase)
SB  - IM
MH  - Amino Acid Substitution/genetics
MH  - Asparagine/*genetics
MH  - Coronary Disease/enzymology/genetics
MH  - Diabetes Mellitus, Type 2/enzymology/genetics
MH  - Dyslipidemias/enzymology/genetics
MH  - Humans
MH  - Lipoprotein Lipase/chemistry/*genetics/metabolism
MH  - Models, Molecular
MH  - Protein Structure, Tertiary
MH  - Serine/*genetics
RF  - 44
EDAT- 2006/06/03 09:00
MHDA- 2006/10/05 09:00
CRDT- 2006/06/03 09:00
PHST- 2006/06/03 09:00 [pubmed]
PHST- 2006/10/05 09:00 [medline]
PHST- 2006/06/03 09:00 [entrez]
AID - S0022-2275(20)43457-1 [pii]
AID - 10.1194/jlr.M600108-JLR200 [doi]
PST - ppublish
SO  - J Lipid Res. 2006 Sep;47(9):1908-14. doi: 10.1194/jlr.M600108-JLR200. Epub 2006 
      Jun 1.