PMID- 16741891
OWN - NLM
STAT- MEDLINE
DCOM- 20060807
LR  - 20071114
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 194
IP  - 1
DP  - 2006 Jul 1
TI  - The role of soluble tumor necrosis factor receptor types I and II and tumor 
      necrosis factor-alpha in malaria during pregnancy.
PG  - 123-32
AB  - In a prospective study of rhesus monkeys inoculated with Plasmodium coatneyi or 
      saline on an infection/gestational timeline, we determined the serum levels of 
      tumor necrosis factor-alpha (TNF-alpha), soluble tumor necrosis factor receptor 
      type I (sTNFR-I), and soluble tumor necrosis factor receptor type II (sTNFR-II) 
      in peripheral blood throughout primigravid pregnancy, malaria infection, and a 
      combination of the two. Our goal was to determine the association between levels 
      of TNF-alpha and of its 2 soluble receptors and the course of pregnancy and/or 
      malaria and infant outcome. We found that any detectable level of TNF-alpha was 
      always associated with fetal death and that the sTNFRs may be important for fetal 
      protection, possibly through neutralizing the toxic effects of TNF-alpha. Our 
      findings also showed that increased levels of sTNFR-II were associated 
      specifically with malaria and not with normal pregnancy or even pregnancy with 
      low birth weight due to other causes. In contrast, increases in sTNFR-I levels 
      during the later half of normal pregnancies indicate that sTNFR-I may be 
      important in regulating TNF-alpha levels in preparation for normal labor and 
      delivery.
FAU - Davison, Billie B
AU  - Davison BB
AD  - Division of Comparative Pathology, Tulane National Primate Research Center, 
      Covington, Louisiana 70433, USA. bdaviso@tulane.edu
FAU - Kaack, M Bernice
AU  - Kaack MB
FAU - Rogers, Linda B
AU  - Rogers LB
FAU - Rasmussen, Kelsi K
AU  - Rasmussen KK
FAU - Rasmussen, Terri A
AU  - Rasmussen TA
FAU - Henson, Elizabeth W
AU  - Henson EW
FAU - Henson, Michael C
AU  - Henson MC
FAU - Parekh, Falgunee K
AU  - Parekh FK
FAU - Krogstad, Donald J
AU  - Krogstad DJ
LA  - eng
GR  - P51RR00164/RR/NCRR NIH HHS/United States
GR  - R01AI42400/AI/NIAID NIH HHS/United States
GR  - UR 3/CCU 418652-03/PHS HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20060526
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Receptors, Tumor Necrosis Factor, Type I)
RN  - 0 (Receptors, Tumor Necrosis Factor, Type II)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Animals
MH  - Birth Weight
MH  - Blood Cell Count
MH  - Disease Models, Animal
MH  - Female
MH  - Fetal Death/parasitology
MH  - Macaca mulatta
MH  - Malaria/*physiopathology
MH  - Plasmodium/*pathogenicity
MH  - Pregnancy
MH  - Pregnancy Complications, Parasitic/*physiopathology
MH  - Prospective Studies
MH  - Receptors, Tumor Necrosis Factor, Type I/blood/*immunology
MH  - Receptors, Tumor Necrosis Factor, Type II/blood/*immunology
MH  - Time Factors
MH  - Tumor Necrosis Factor-alpha/analysis/*immunology
EDAT- 2006/06/03 09:00
MHDA- 2006/08/08 09:00
CRDT- 2006/06/03 09:00
PHST- 2006/01/26 00:00 [received]
PHST- 2006/02/17 00:00 [accepted]
PHST- 2006/06/03 09:00 [pubmed]
PHST- 2006/08/08 09:00 [medline]
PHST- 2006/06/03 09:00 [entrez]
AID - JID36279 [pii]
AID - 10.1086/504694 [doi]
PST - ppublish
SO  - J Infect Dis. 2006 Jul 1;194(1):123-32. doi: 10.1086/504694. Epub 2006 May 26.