PMID- 16741941
OWN - NLM
STAT- MEDLINE
DCOM- 20060816
LR  - 20200930
IS  - 1552-4841 (Print)
IS  - 1552-4841 (Linking)
VI  - 141B
IP  - 5
DP  - 2006 Jul 5
TI  - Transmission distortion of BDNF variants to bipolar disorder type I patients from 
      a South American population isolate.
PG  - 435-9
AB  - Recent reports have implicated polymorphisms in the brain derived neurotrophic 
      factor (BDNF) gene region in the etiology of several psychiatric phenotypes, 
      including bipolar disorder. Significant disease association has been reported for 
      the G allele at SNP rs6265, which encodes for Valine at position 66 of BDNF 
      (Val66Met), an apparently functional variant of this key BDNF. Here we examined a 
      sample of 224 bipolar type I patients and available parents (comprising a total 
      of 212 nuclear families) ascertained in a South American population isolate 
      (Antioquia, Colombia). We tested for transmission distortion to bipolar patients 
      of alleles at the rs6265 polymorphism and at a microsatellite marker 1.3 kb away 
      from this SNP. Significant excess transmission of the rs6265 G allele to cases 
      was observed (chi(2) = 10.77, d.f. = 1, P = 0.001). Two-locus haplotype analysis 
      showed a significant global transmission distortion (chi(2) = 16.059, d.f. = 7, P 
      = 0.025) with an excess transmission of a haplotype comprising the rs6265 G 
      allele and microsatellite allele 227. These results are consistent with previous 
      studies pointing to a role for BDNF in susceptibility to mood disorders.
CI  - (c) 2006 Wiley-Liss, Inc.
FAU - Kremeyer, Barbara
AU  - Kremeyer B
AD  - Galton Laboratory, Department of Biology, University College London, London, 
      United Kingdom.
FAU - Herzberg, Ibi
AU  - Herzberg I
FAU - Garcia, Jenny
AU  - Garcia J
FAU - Kerr, Emily
AU  - Kerr E
FAU - Duque, Constanza
AU  - Duque C
FAU - Parra, Vicky
AU  - Parra V
FAU - Vega, Jorge
AU  - Vega J
FAU - Lopez, Carlos
AU  - Lopez C
FAU - Palacio, Carlos
AU  - Palacio C
FAU - Bedoya, Gabriel
AU  - Bedoya G
FAU - Ospina, Jorge
AU  - Ospina J
FAU - Ruiz-Linares, Andres
AU  - Ruiz-Linares A
LA  - eng
GR  - 086052/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Med Genet B Neuropsychiatr Genet
JT  - American journal of medical genetics. Part B, Neuropsychiatric genetics : the 
      official publication of the International Society of Psychiatric Genetics
JID - 101235742
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Alleles
MH  - Bipolar Disorder/*genetics
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Colombia
MH  - Dinucleotide Repeats/genetics
MH  - Family Health
MH  - Female
MH  - Gene Frequency
MH  - Haplotypes
MH  - Humans
MH  - Linkage Disequilibrium
MH  - Male
MH  - Mutation, Missense
MH  - Nuclear Family
MH  - *Polymorphism, Single Nucleotide
EDAT- 2006/06/03 09:00
MHDA- 2006/08/17 09:00
CRDT- 2006/06/03 09:00
PHST- 2006/06/03 09:00 [pubmed]
PHST- 2006/08/17 09:00 [medline]
PHST- 2006/06/03 09:00 [entrez]
AID - 10.1002/ajmg.b.30354 [doi]
PST - ppublish
SO  - Am J Med Genet B Neuropsychiatr Genet. 2006 Jul 5;141B(5):435-9. doi: 
      10.1002/ajmg.b.30354.