PMID- 16750781
OWN - NLM
STAT- MEDLINE
DCOM- 20070116
LR  - 20181113
IS  - 1071-3581 (Print)
IS  - 1071-3581 (Linking)
VI  - 13
IP  - 3
DP  - 2006 May-Jun
TI  - Value of peripheral vascular endothelial function in the detection of relative 
      myocardial ischemia in asymptomatic type 2 diabetic patients who underwent 
      myocardial perfusion imaging.
PG  - 362-8
AB  - BACKGROUND: Endothelial dysfunction precedes overt atherosclerosis and is present 
      in patients with type 2 diabetes mellitus (T2DM). Myocardial perfusion imaging 
      (MPI) is an effective method of detection of coronary artery disease (CAD); 
      however, the relationship between endothelial function and MPI in asymptomatic 
      patients with T2DM has not been examined. METHODS AND RESULTS: This study used a 
      subset of the population from the Detection of Ischemia in Asymptomatic Diabetics 
      (DIAD) study. Endothelium-dependent vasodilation (EDV) and 
      endothelium-independent vasodilation (EIV) were measured by use of brachial 
      artery ultrasonography in 75 asymptomatic patients with T2DM (56 men; mean age, 
      58.6 +/- 6.4 years; mean duration of diabetes, 8.4 +/- 7.5 years) who underwent 
      adenosine MPI. Of the patients, 15 (20%) had evidence of relative ischemia 
      (MPI(+)) whereas 60 (80%) had a normal study (MPI(-)). Both EDV (3.5% +/- 3.7% vs 
      4.5% +/- 6.6%, P = not significant) and EIV (15.1% +/- 7.5% vs 16.8% +/- 8.4%, P 
      = not significant) were similar in the 2 groups. On the basis of a 
      receiver-operator analysis, an EDV response of 8% was selected as a cut point, 
      with a negative predictive value of 93% (13/14 subjects with EDV >or=8% were 
      MPI(-)). CONCLUSIONS: Endothelial function in asymptomatic patients with T2DM is 
      not associated with the presence of relative myocardial ischemia by MPI; however, 
      an EDV of 8% or greater has a high negative predictive value for the exclusion of 
      CAD.
FAU - Papaioannou, Georgios I
AU  - Papaioannou GI
AD  - Henry Low Heart Center, Cardiology Division, Hartford Hospital, CT 06102, USA.
FAU - Kasapis, Christos
AU  - Kasapis C
FAU - Seip, Richard L
AU  - Seip RL
FAU - Grey, Neil J
AU  - Grey NJ
FAU - Katten, Deborah
AU  - Katten D
FAU - Wackers, Frans J Th
AU  - Wackers FJ
FAU - Inzucchi, Silvio E
AU  - Inzucchi SE
FAU - Engel, Samuel
AU  - Engel S
FAU - Taylor, Amy
AU  - Taylor A
FAU - Young, Lawrence H
AU  - Young LH
FAU - Chyun, Deborah A
AU  - Chyun DA
FAU - Davey, Janice A
AU  - Davey JA
FAU - Iskandrian, Ami E
AU  - Iskandrian AE
FAU - Ratner, Robert E
AU  - Ratner RE
FAU - Robinson, Evelyn C
AU  - Robinson EC
FAU - Carolan, Stella
AU  - Carolan S
FAU - Heller, Gary V
AU  - Heller GV
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Nucl Cardiol
JT  - Journal of nuclear cardiology : official publication of the American Society of 
      Nuclear Cardiology
JID - 9423534
RN  - 0 (Vasodilator Agents)
RN  - G59M7S0WS3 (Nitroglycerin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 2/*complications/metabolism/*pathology
MH  - Endothelium, Vascular/*pathology
MH  - Female
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Ischemia/pathology
MH  - Male
MH  - Middle Aged
MH  - Myocardial Ischemia/*complications/*pathology
MH  - Myocardium/pathology
MH  - Nitroglycerin/pharmacology
MH  - Perfusion
MH  - Vasodilator Agents/pharmacology
EDAT- 2006/06/06 09:00
MHDA- 2007/01/17 09:00
CRDT- 2006/06/06 09:00
PHST- 2005/08/16 00:00 [received]
PHST- 2006/01/30 00:00 [accepted]
PHST- 2006/06/06 09:00 [pubmed]
PHST- 2007/01/17 09:00 [medline]
PHST- 2006/06/06 09:00 [entrez]
AID - S1071-3581(06)00115-2 [pii]
AID - 10.1016/j.nuclcard.2006.01.022 [doi]
PST - ppublish
SO  - J Nucl Cardiol. 2006 May-Jun;13(3):362-8. doi: 10.1016/j.nuclcard.2006.01.022.