PMID- 16750782
OWN - NLM
STAT- MEDLINE
DCOM- 20070116
LR  - 20181113
IS  - 1071-3581 (Print)
IS  - 1071-3581 (Linking)
VI  - 13
IP  - 3
DP  - 2006 May-Jun
TI  - Hypertensive left ventricular hypertrophy is associated with abnormal myocardial 
      fatty acid metabolism and myocardial efficiency.
PG  - 369-77
AB  - BACKGROUND: Hypertension-induced left ventricular hypertrophy (LVH) is associated 
      with an increased risk of cardiovascular morbidity and death by mechanisms not 
      well characterized. METHODS AND RESULTS: Myocardial fatty acid (FA) metabolism 
      and left ventricular (LV) mass were evaluated in 13 patients with hypertensive 
      LVH with normal LV ejection fraction and 42 normal control subjects (primary 
      cohort). Contractile performance was also evaluated in 5 hypertensive LVH 
      patients and 5 matched normal control subjects (magnetic resonance [MR] 
      substudy). Myocardial FA utilization (MFAU) and myocardial FA oxidation (MFAO) 
      were assessed by positron emission tomography by use of 1-carbon-11 palmitate. 
      Myocardial contractile function (strain and stress) was determined by cardiac MR 
      imaging with tissue tagging and calibrated arterial pressure traces; myocardial 
      external minute work and efficiency were derived. In the primary cohort decreased 
      MFAO was predictive of increased LV mass (model r(2) = 0.61, P = .03). In the MR 
      substudy decreased MFAO (corrected for myocardial oxygen consumption [MVO(2)]) in 
      the hypertensive LVH group compared with the normal group (MFAU/MVO(2), 26 +/- 5 
      vs 37 +/- 8; MFAO/MVO(2), 24 +/- 6 vs 35 +/- 7; both P = .03) was paralleled by 
      decreased myocardial external minute work (0.13 +/- 0.03 J x g(-1) x min(-1) vs 
      0.17 +/- 0.04 J x g(-1) x min(-1), P = .07) and decreased myocardial efficiency 
      (5.2% +/- 1.4% vs 7.1% +/- 1.0%, P = .03). CONCLUSIONS: Abnormalities in 
      myocardial FA metabolism are apparent in hypertensive LVH, and these 
      abnormalities may be responsible, at least in part, for a reduction in myocardial 
      efficiency.
FAU - de las Fuentes, Lisa
AU  - de las Fuentes L
AD  - Cardiovascular Imaging and Clinical Research Core Laboratory, Department of 
      Medicine, Cardiovascular Division, Washington University School of Medicine, St 
      Louis, MO, USA. lfuentes@im.wustl.edu
FAU - Soto, Pablo F
AU  - Soto PF
FAU - Cupps, Brian P
AU  - Cupps BP
FAU - Pasque, Michael K
AU  - Pasque MK
FAU - Herrero, Pilar
AU  - Herrero P
FAU - Gropler, Robert J
AU  - Gropler RJ
FAU - Waggoner, Alan D
AU  - Waggoner AD
FAU - Davila-Roman, Victor G
AU  - Davila-Roman VG
LA  - eng
GR  - R01HL58878/HL/NHLBI NIH HHS/United States
GR  - L30 HL074749-03/HL/NHLBI NIH HHS/United States
GR  - P30 DK056341/DK/NIDDK NIH HHS/United States
GR  - P30 DK056341-06/DK/NIDDK NIH HHS/United States
GR  - R01HL71782/HL/NHLBI NIH HHS/United States
GR  - R01AG15466/AG/NIA NIH HHS/United States
GR  - L30 HL074749/HL/NHLBI NIH HHS/United States
GR  - P01HL13851/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Nucl Cardiol
JT  - Journal of nuclear cardiology : official publication of the American Society of 
      Nuclear Cardiology
JID - 9423534
RN  - 0 (Fatty Acids)
RN  - 0 (Insulin)
RN  - 0 (Palmitic Acids)
SB  - IM
MH  - Aged
MH  - Calibration
MH  - Cohort Studies
MH  - Fatty Acids/*metabolism
MH  - Female
MH  - Heart/*physiology
MH  - Humans
MH  - Hypertension/*complications
MH  - Hypertrophy, Left Ventricular/*complications/*diagnosis
MH  - Insulin/metabolism
MH  - Male
MH  - Middle Aged
MH  - Myocardial Contraction
MH  - Myocardium/*metabolism
MH  - Palmitic Acids/metabolism
MH  - Positron-Emission Tomography/methods
EDAT- 2006/06/06 09:00
MHDA- 2007/01/17 09:00
CRDT- 2006/06/06 09:00
PHST- 2005/06/14 00:00 [received]
PHST- 2006/01/30 00:00 [accepted]
PHST- 2006/06/06 09:00 [pubmed]
PHST- 2007/01/17 09:00 [medline]
PHST- 2006/06/06 09:00 [entrez]
AID - S1071-3581(06)00114-0 [pii]
AID - 10.1016/j.nuclcard.2006.01.021 [doi]
PST - ppublish
SO  - J Nucl Cardiol. 2006 May-Jun;13(3):369-77. doi: 10.1016/j.nuclcard.2006.01.021.