PMID- 16753591
OWN - NLM
STAT- MEDLINE
DCOM- 20060727
LR  - 20151119
IS  - 0002-9173 (Print)
IS  - 0002-9173 (Linking)
VI  - 126
IP  - 1
DP  - 2006 Jul
TI  - The usefulness of CD71 expression by flow cytometry for differentiating indolent 
      from aggressive CD10+ B-cell lymphomas.
PG  - 39-46
AB  - We studied 34 low- and 30 high-grade CD10+ B-cell lymphomas. Forward light 
      scatter (FSC) and CD71 fluorescence intensity (CD71i) of tumor cells were 
      measured and normalized by corresponding values for resting T cells. Significant 
      differences in CD71i values between low- and high-grade lymphomas were observed 
      by the Mann-Whitney U test (P < .001) and receiver operating characteristic (ROC) 
      curve analysis (P < .001). FSC was not significantly different between low- and 
      high-grade lymphomas; the area under the ROC curve was less than that for CD71i. 
      Neither FSC nor CD71i significantly differentiated follicular lymphoma (FL) 
      grades. A comparison of all FLs (grades 1-3) and non-FL high-grade lymphomas 
      (Burkitt lymphoma [BL] and large B-cell lymphoma [LBCL]) showed significant 
      differences in CD71i (P < .001) and FSC (P = .021). Differences were significant 
      in CD71i and FSC between FL and LBCL (P < .001) but not between FL and BL. CD71i 
      is more potent than FSC for distinguishing CD10+ low- from high-grade lymphomas 
      and FL from non-FL high-grade lymphomas. Sensitivity and specificity are limited 
      owing to inability to identify FL3. In ROC analysis, a high value for CD71i can 
      identify BL and LBCL with a high degree of certainty.
FAU - Wu, Julie M
AU  - Wu JM
AD  - Department of Pathology, Johns Hopkins Medical, Institutions, Baltimore, MD, USA.
FAU - Borowitz, Michael J
AU  - Borowitz MJ
FAU - Weir, Edward G
AU  - Weir EG
LA  - eng
PT  - Journal Article
PL  - England
TA  - Am J Clin Pathol
JT  - American journal of clinical pathology
JID - 0370470
RN  - 0 (Antigens, CD)
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (CD71 antigen)
RN  - 0 (Receptors, Transferrin)
RN  - EC 3.4.24.11 (Neprilysin)
SB  - IM
MH  - Antigens, CD/*metabolism
MH  - Biomarkers, Tumor/metabolism
MH  - Diagnosis, Differential
MH  - Flow Cytometry/instrumentation/*methods
MH  - Humans
MH  - Immunophenotyping/*methods
MH  - Light
MH  - Lymphoma, B-Cell/classification/metabolism/*pathology
MH  - Neprilysin/metabolism
MH  - ROC Curve
MH  - Receptors, Transferrin/*metabolism
MH  - Retrospective Studies
MH  - Scattering, Radiation
EDAT- 2006/06/07 09:00
MHDA- 2006/07/28 09:00
CRDT- 2006/06/07 09:00
PHST- 2006/06/07 09:00 [pubmed]
PHST- 2006/07/28 09:00 [medline]
PHST- 2006/06/07 09:00 [entrez]
AID - X8LBRRBBC43PL9HC [pii]
AID - 10.1309/X8LB-RRBB-C43P-L9HC [doi]
PST - ppublish
SO  - Am J Clin Pathol. 2006 Jul;126(1):39-46. doi: 10.1309/X8LB-RRBB-C43P-L9HC.