PMID- 16754518
OWN - NLM
STAT- MEDLINE
DCOM- 20060627
LR  - 20181201
IS  - 0277-0903 (Print)
IS  - 0277-0903 (Linking)
VI  - 43
IP  - 3
DP  - 2006 Apr
TI  - Gender differences in IgE-mediated allergic asthma in the epidemiology and 
      natural history of asthma: Outcomes and Treatment Regimens (TENOR) study.
PG  - 179-84
AB  - BACKGROUND: The TENOR study consists of a large cohort of subjects with severe or 
      difficult-to-treat asthma. The objective of this analysis was to evaluate 
      demographic and clinical characteristics of subjects 12 years of age or older 
      with immunoglobulin E (IgE)-mediated allergic asthma (skin test positive with an 
      IgE level = 30 to =700 IU/mL), and specifically, to assess gender differences in 
      this cohort. METHODS: A total of 4,756 subjects were enrolled by 283 US study 
      sites between January and October 2001. Of those subjects 12 years or older at 
      baseline with an IgE measure and who were skin tested (n = 2,843), 1,783 (63%) 
      were skin test positive and had an IgE level between = 30 to = 700 IU/mL. 
      RESULTS: Compared to males, females reported significantly greater healthcare 
      utilization (steroid bursts in previous 3 months: 50% vs 42%, p < 0.001; 
      unscheduled office visits in previous 3 months: 50% vs 36%, p < 0.0001; missed 1+ 
      days of work/school in previous 2 weeks: 14% vs 10%, p < 0.01). Females also 
      reported significantly more asthma control problems and lower asthma-related 
      quality of life (4.6 +/- 1.3 vs 5.2 +/- 1.2; p < 0.0001); the difference was 
      clinically meaningful. Asthma triggers and allergic comorbidities, such as 
      allergic rhinitis and atopic dermatitis, were more common in female subjects. 
      Despite their overall worse health outcomes, female subjects demonstrated better 
      lung function, had similar treatment patterns, and showed no differences in 
      physician-assessed asthma severity when compared with males. CONCLUSIONS: The 
      reasons for these gender differences in subjects with IgE-mediated allergic 
      asthma are complex, but results from this analysis suggest that detailed 
      evaluations of asthma patients, including symptom-related questions and 
      asthma-related healthcare utilization, are needed to accurately assess asthma 
      severity and control.
FAU - Lee, June H
AU  - Lee JH
AD  - Genentech, Inc., South San Francisco, California 94080, USA. junelee@gene.com
FAU - Haselkorn, Tmirah
AU  - Haselkorn T
FAU - Chipps, Bradley E
AU  - Chipps BE
FAU - Miller, Dave P
AU  - Miller DP
FAU - Wenzel, Sally E
AU  - Wenzel SE
CN  - Tenor Study Group
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Asthma
JT  - The Journal of asthma : official journal of the Association for the Care of 
      Asthma
JID - 8106454
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Asthma/*epidemiology/*immunology
MH  - Child
MH  - Female
MH  - Health Services/statistics & numerical data
MH  - Humans
MH  - Immunoglobulin E/*immunology
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Quality of Life
MH  - Respiratory Function Tests
MH  - Sex Factors
MH  - Skin Tests
EDAT- 2006/06/07 09:00
MHDA- 2006/06/28 09:00
CRDT- 2006/06/07 09:00
PHST- 2006/06/07 09:00 [pubmed]
PHST- 2006/06/28 09:00 [medline]
PHST- 2006/06/07 09:00 [entrez]
AID - Q30721586P17Q34V [pii]
AID - 10.1080/02770900600566405 [doi]
PST - ppublish
SO  - J Asthma. 2006 Apr;43(3):179-84. doi: 10.1080/02770900600566405.