PMID- 16756035 OWN - NLM STAT- MEDLINE DCOM- 20070320 LR - 20060607 IS - 0033-2674 (Print) IS - 0033-2674 (Linking) VI - 40 IP - 1 DP - 2006 Jan-Feb TI - [Stressful events in childhood and psychiatric disorders in the elderly]. PG - 129-38 AB - Neurotrophins have been implicated in the regulation of development, neuronal survival, and adult synaptic plasticity. Brain-derived neurotrophic factor (BDNF) plays an important role in development, synapse remodelling and responses to stress and injury. Its abnormal expression has been implicated in many neuropsychiatric disorders. Adverse life events occurring early in development may alter the expression of brain-derived neurotrophic factor (BDNF) in the hippocampus and other brain areas and render the organism more vulnerable to psychiatric disorders. FAU - Bidzan, Leszek AU - Bidzan L AD - Klinika Psychiatrii Rozwojowej, Zaburzen Psychotycznych i Wieku Podeszlego AM w Gdansku. LA - pol PT - English Abstract PT - Journal Article PT - Review TT - Wydarzenia niekorzystne w okresie dziecinstwa a zaburzenia psychiczne w wieku podeszlym. PL - Poland TA - Psychiatr Pol JT - Psychiatria polska JID - 0103314 RN - 0 (Brain-Derived Neurotrophic Factor) SB - IM MH - Adult MH - Aged MH - Aging/*physiology MH - Brain/*metabolism MH - Brain-Derived Neurotrophic Factor/*metabolism MH - Child MH - Child Development MH - Developmental Disabilities/*metabolism MH - Hippocampus/metabolism MH - Humans MH - Life Change Events MH - Stress, Psychological/*metabolism RF - 46 EDAT- 2006/06/08 09:00 MHDA- 2007/03/21 09:00 CRDT- 2006/06/08 09:00 PHST- 2006/06/08 09:00 [pubmed] PHST- 2007/03/21 09:00 [medline] PHST- 2006/06/08 09:00 [entrez] PST - ppublish SO - Psychiatr Pol. 2006 Jan-Feb;40(1):129-38.