PMID- 16756886
OWN - NLM
STAT- MEDLINE
DCOM- 20061026
LR  - 20190917
IS  - 1695-4033 (Print)
IS  - 1695-4033 (Linking)
VI  - 64
IP  - 5
DP  - 2006 May
TI  - [Genomic profile in high risk neuroblastoma by comparative genomic 
      hybridization].
PG  - 449-56
AB  - Different subtypes of neuroblastoma (NB) carry associated genetic aberrations 
      that predict their clinical course. Whole chromosome gains are usually associated 
      with early clinical stages and good prognosis, while 1p deletion, 17q gain and 
      MYCN amplification (MNA) are related to advanced stages and poor prognosis. 
      High-risk neuroblastomas (NB-HR) include NB in children aged more than 1 year 
      old, either stage 4 or any stages showing MNA except stage 1. The prognosis of 
      NB-HR patients remains poor, despite aggressive therapy. Only MNA confers poor 
      prognosis. Between January 2000 and February 2005, tumoral specimens from 60 
      patients with NB-HR were sent to the Spanish Reference Center for NB biological 
      studies. In all cases, MYCN together with 1p36 status was analyzed by 
      fluorescence in situ hybridization (FISH). Comparative genomic hybridization 
      (CGH) was performed in 24 cases. Using FISH we detected 31 MNA cases including 29 
      with 1p36 deletion; there were 21 cases without MYCN amplification (MNNA) but 7 
      of these had 1p36 deletion; 8 cases showed MYCN gain (MNG) but 6 of these had 
      1p36 deletion. CGH showed other chromosomal alterations. Of 11 MNA cases, none 
      had 11q loss and all of them showed 17q gain or 17 disomy. Of the 7 MNNA cases, 
      there were 4 with 11q loss including 2 with 3p loss and all presented 17q gain or 
      17 disomy. The 6 MNG cases included 4 cases with 11q loss and 5 cases with 17q 
      gain or 17 disomy. Genomic profiling by CGH in NB-HR confirms the interaction 
      among genetic alterations, the prognostic significance of which should be 
      evaluated to establish new treatment criteria.
FAU - Noguera Salva, R
AU  - Noguera Salva R
AD  - Departamento de Patologia, Facultad de Medicina y Odontologia, Universidad de 
      Valencia, Espana. rosa.noguer@uv.es
FAU - Piqueras Franco, M
AU  - Piqueras Franco M
FAU - Ruiz Sauri, A
AU  - Ruiz Sauri A
FAU - Llombart-Bosch, A
AU  - Llombart-Bosch A
FAU - Castel Sanchez, V
AU  - Castel Sanchez V
FAU - Navarro Fos, S
AU  - Navarro Fos S
LA  - spa
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
TT  - Perfil genomico del neuroblastoma de alto riesgo mediante hibridacion genomica 
      comparada.
PL  - Spain
TA  - An Pediatr (Barc)
JT  - Anales de pediatria (Barcelona, Spain : 2003)
JID - 101162596
SB  - IM
MH  - Female
MH  - *Genomics
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence
MH  - Infant
MH  - Male
MH  - Neuroblastoma/*genetics
MH  - Risk Factors
EDAT- 2006/06/08 09:00
MHDA- 2006/10/27 09:00
CRDT- 2006/06/08 09:00
PHST- 2006/06/08 09:00 [pubmed]
PHST- 2006/10/27 09:00 [medline]
PHST- 2006/06/08 09:00 [entrez]
AID - 13087872 [pii]
AID - 10.1157/13087872 [doi]
PST - ppublish
SO  - An Pediatr (Barc). 2006 May;64(5):449-56. doi: 10.1157/13087872.