PMID- 16758368
OWN - NLM
STAT- MEDLINE
DCOM- 20070322
LR  - 20181113
IS  - 0364-3190 (Print)
IS  - 0364-3190 (Linking)
VI  - 31
IP  - 4
DP  - 2006 Apr
TI  - GMF-knockout mice are unable to induce brain-derived neurotrophic factor after 
      exercise.
PG  - 579-84
AB  - We earlier reported that overexpression of glia maturation factor (GMF) in 
      cultured astrocytes enhances the production of brain-derived neurotrophic factor 
      (BDNF). The current study was conducted to find out whether BDNF production is 
      impaired in animals devoid of GMF. To this end GMF-knockout (KO) mice were 
      subjected to exercise and the neurotrophin mRNAs were determined by real-time 
      RT-PCR. Compared to wild-type (WT) mice, there is a decrease in exercise-induced 
      BDNF in the KO mice. The observation was correlated with the finding that, in WT 
      mice, exercise increases GMF expression. The results are consistent with the 
      hypothesis that GMF is necessary for exercise-induction of BDNF, and that GMF may 
      promote neuroprotection through BDNF production.
FAU - Zaheer, Asgar
AU  - Zaheer A
AD  - Department of Neurology (Division of Neurochemistry and Neurobiology), Veterans 
      Affairs Medical Center and University of Iowa College of Medicine, Iowa City, 
      52242, USA. asgar-zaheer@uiowa.edu
FAU - Haas, Joel T
AU  - Haas JT
FAU - Reyes, Carlos
AU  - Reyes C
FAU - Mathur, Satya N
AU  - Mathur SN
FAU - Yang, Baoli
AU  - Yang B
FAU - Lim, Ramon
AU  - Lim R
LA  - eng
GR  - NS-47145/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20060513
PL  - United States
TA  - Neurochem Res
JT  - Neurochemical research
JID - 7613461
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Glia Maturation Factor)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Neurotrophin 3)
RN  - 0 (RNA, Messenger)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Female
MH  - Glia Maturation Factor/genetics/*metabolism
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Nerve Growth Factor/genetics/metabolism
MH  - Neuroprotective Agents/metabolism
MH  - Neurotrophin 3/genetics/metabolism
MH  - *Physical Conditioning, Animal
MH  - RNA, Messenger/metabolism
EDAT- 2006/06/08 09:00
MHDA- 2007/03/23 09:00
CRDT- 2006/06/08 09:00
PHST- 2006/01/31 00:00 [accepted]
PHST- 2006/06/08 09:00 [pubmed]
PHST- 2007/03/23 09:00 [medline]
PHST- 2006/06/08 09:00 [entrez]
AID - 10.1007/s11064-006-9049-3 [doi]
PST - ppublish
SO  - Neurochem Res. 2006 Apr;31(4):579-84. doi: 10.1007/s11064-006-9049-3. Epub 2006 
      May 13.