PMID- 1675920
OWN - NLM
STAT- MEDLINE
DCOM- 19910801
LR  - 20190613
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 542
IP  - 1
DP  - 1991 Feb 22
TI  - Modification of the responses of primate spinothalamic neurons to mechanical 
      stimulation by excitatory amino acids and an N-methyl-D-aspartate antagonist.
PG  - 15-22
AB  - Excitatory amino acids (EAAs) are likely to play a key role in sensory 
      transmission in the spinal cord. In the present study, the microiontophoresis 
      technique was used to investigate the effects of L-glutamate (GLUT), 
      N-methyl-D-aspartate (NMDA), and quisqualate (QUIS), as well as an NMDA receptor 
      antagonist, AP-7, on the discharges evoked in nociceptive primate spinothalamic 
      tract (STT) neurons by mechanical stimulation of the skin. Responses to innocuous 
      brushing of the skin were facilitated by GLUT and NMDA (and in some neurons by 
      QUIS) and sometimes reduced by AP-7. GLUT also facilitated the responses to 
      noxious mechanical stimuli. The results are consistent with anatomical evidence 
      for the presence of synapses that contain EAAs on primate STT cells and with the 
      proposal that the co-release of EAAs and neuropeptides may contribute to 
      hyperalgesia.
FAU - Dougherty, P M
AU  - Dougherty PM
AD  - Department of Anatomy and Neurosciences, University of Texas Medical Branch, 
      Galveston 77550-2772.
FAU - Willis, W D
AU  - Willis WD
LA  - eng
GR  - NS08860/NS/NINDS NIH HHS/United States
GR  - NS09743/NS/NINDS NIH HHS/United States
GR  - NS11255/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Amino Acids)
RN  - 0 (Glutamates)
RN  - 3KX376GY7L (Glutamic Acid)
RN  - 6384-92-5 (N-Methylaspartate)
RN  - 76726-92-6 (2-Amino-5-phosphonovalerate)
RN  - 8OC22C1B99 (Quisqualic Acid)
RN  - P34K80CUSM (2-amino-7-phosphonoheptanoic acid)
SB  - IM
MH  - *2-Amino-5-phosphonovalerate/*analogs & derivatives
MH  - Amino Acids/*pharmacology
MH  - Animals
MH  - Glutamates/pharmacology
MH  - Glutamic Acid
MH  - Macaca fascicularis
MH  - N-Methylaspartate/*antagonists & inhibitors/pharmacology
MH  - Neurons/*drug effects
MH  - Quisqualic Acid/pharmacology
MH  - Spinothalamic Tracts/cytology/*drug effects
EDAT- 1991/02/22 00:00
MHDA- 1991/02/22 00:01
CRDT- 1991/02/22 00:00
PHST- 1991/02/22 00:00 [pubmed]
PHST- 1991/02/22 00:01 [medline]
PHST- 1991/02/22 00:00 [entrez]
AID - 0006-8993(91)90991-4 [pii]
AID - 10.1016/0006-8993(91)90991-4 [doi]
PST - ppublish
SO  - Brain Res. 1991 Feb 22;542(1):15-22. doi: 10.1016/0006-8993(91)90991-4.