PMID- 16759896
OWN - NLM
STAT- MEDLINE
DCOM- 20071120
LR  - 20220330
IS  - 1368-8375 (Print)
IS  - 1368-8375 (Linking)
VI  - 43
IP  - 1
DP  - 2007 Jan
TI  - Metastasis of squamous cell carcinoma of the oral tongue is associated with 
      down-regulation of epidermal fatty acid binding protein (E-FABP).
PG  - 27-32
AB  - Squamous cell carcinoma (SCC) of the tongue is one of the most common cancers 
      encountered in India, due to the prevalent habits of tobacco chewing and smoking. 
      Up to 40% of the early stage tumours (clinical N0 M0) presenting at the Tata 
      Memorial Hospital have occult cervical lymph node metastasis. Therefore, features 
      in the primary tumour that would predict metastasis would be very useful for 
      designing therapeutic approaches. Hence, we aimed at detecting genotypic markers 
      of the metastatic sub-clones within the heterogeneous primary tumour population. 
      We studied the differential expression of mRNAs between the primary tumour 
      samples of SCC of the oral tongue and their metastasis by differential display 
      analysis and identified a gene, FABP5, coding for Epidermal fatty acid binding 
      protein (E-FABP-GenBank Accession ). Its expression was up to 4-fold higher in 
      the primary tumours (67%) as compared to the corresponding metastatic lymph nodes 
      by northern blot analysis.
FAU - Uma, Ramanathan S
AU  - Uma RS
AD  - Department of Pathology, Tata Memorial Hospital, Dr. Ernest Borges Road, Parel, 
      Mumbai 400 012, India. umaramnathan@hotmail.com
FAU - Naresh, Kikkeri N
AU  - Naresh KN
FAU - D'Cruz, Anil K
AU  - D'Cruz AK
FAU - Mulherkar, Rita
AU  - Mulherkar R
FAU - Borges, Anita M
AU  - Borges AM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060608
PL  - England
TA  - Oral Oncol
JT  - Oral oncology
JID - 9709118
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (FABP5 protein, human)
RN  - 0 (Fatty Acid-Binding Proteins)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers, Tumor/*metabolism
MH  - Blotting, Northern
MH  - Carcinoma, Squamous Cell/*metabolism
MH  - Down-Regulation
MH  - Fatty Acid-Binding Proteins/*metabolism
MH  - Head and Neck Neoplasms/metabolism/*secondary
MH  - Humans
MH  - *Lymph Nodes
MH  - Lymphatic Metastasis
MH  - Middle Aged
MH  - RNA, Messenger/metabolism
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Tongue Neoplasms/*metabolism
EDAT- 2006/06/09 09:00
MHDA- 2007/12/06 09:00
CRDT- 2006/06/09 09:00
PHST- 2005/11/15 00:00 [received]
PHST- 2005/12/16 00:00 [revised]
PHST- 2005/12/19 00:00 [accepted]
PHST- 2006/06/09 09:00 [pubmed]
PHST- 2007/12/06 09:00 [medline]
PHST- 2006/06/09 09:00 [entrez]
AID - S1368-8375(06)00002-9 [pii]
AID - 10.1016/j.oraloncology.2005.12.024 [doi]
PST - ppublish
SO  - Oral Oncol. 2007 Jan;43(1):27-32. doi: 10.1016/j.oraloncology.2005.12.024. Epub 
      2006 Jun 8.