PMID- 16759904
OWN - NLM
STAT- MEDLINE
DCOM- 20060905
LR  - 20080910
IS  - 1388-2457 (Print)
IS  - 1388-2457 (Linking)
VI  - 117
IP  - 7
DP  - 2006 Jul
TI  - Generators and temporal succession of giant somatosensory evoked potentials in 
      cortical reflex myoclonus: epicortical recording from sensorimotor cortex.
PG  - 1481-6
AB  - OBJECTIVE: To clarify the generator mechanism of giant somatosensory evoked 
      potentials (giant SEPs) and the hyperexcitability of primary somatosensory and 
      motor cortices (SI and MI). METHODS: In a patient with intractable focal seizures 
      manifesting cortical reflex myoclonus of the left foot, giant SEPs to left tibial 
      nerve stimulation were epicortically recorded as a part of presurgical evaluation 
      with subdural electrodes. RESULTS: In the single pulse SEPs, enlarged P1-N1 
      components were observed at the foot area of the SI and MI (86.5-258.8 microV, 
      respectively), and the peak latencies were always shorter at SI than at MI by 6 
      ms. Similar findings were obtained for peroneal and sural nerve stimulation. In 
      the paired pulse SEPs, the second response was less suppressed, as compared to 
      other interstimulus intervals (ISIs), with ISIs of 40 and 200 ms both at SI and 
      MI. CONCLUSIONS: In this particular patient, cortical hyperexcitability to 
      somatosensory stimuli seems to originate from SI but subsequently both SI and MI 
      are responsible for the generation of giant SEPs and cortical reflex myoclonus. 
      SIGNIFICANCE: Somatosensory and primary motor cortices both generated enhanced 
      early cortical components of SEPs, most likely by enhancing the latter by the 
      former.
FAU - Hitomi, Takefumi
AU  - Hitomi T
AD  - Department of Neurology, Kyoto University Graduate School of Medicine, and Takeda 
      General Hospital, Kyoto, Japan.
FAU - Ikeda, Akio
AU  - Ikeda A
FAU - Matsumoto, Riki
AU  - Matsumoto R
FAU - Kinoshita, Masako
AU  - Kinoshita M
FAU - Taki, Junya
AU  - Taki J
FAU - Usui, Keiko
AU  - Usui K
FAU - Mikuni, Nobuhiro
AU  - Mikuni N
FAU - Nagamine, Takashi
AU  - Nagamine T
FAU - Hashimoto, Nobuo
AU  - Hashimoto N
FAU - Shibasaki, Hiroshi
AU  - Shibasaki H
FAU - Takahashi, Ryosuke
AU  - Takahashi R
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060608
PL  - Netherlands
TA  - Clin Neurophysiol
JT  - Clinical neurophysiology : official journal of the International Federation of 
      Clinical Neurophysiology
JID - 100883319
SB  - IM
MH  - Adult
MH  - Brain Mapping
MH  - Electric Stimulation/methods
MH  - Evoked Potentials, Somatosensory/*physiology
MH  - Functional Laterality
MH  - Humans
MH  - Male
MH  - Motor Cortex/physiopathology
MH  - Myoclonus/*physiopathology
MH  - Peroneal Nerve/physiopathology/radiation effects
MH  - Reaction Time/physiology/radiation effects
MH  - Somatosensory Cortex/*physiopathology
MH  - Tibial Nerve/physiopathology/radiation effects
EDAT- 2006/06/09 09:00
MHDA- 2006/09/06 09:00
CRDT- 2006/06/09 09:00
PHST- 2005/06/25 00:00 [received]
PHST- 2006/03/16 00:00 [revised]
PHST- 2006/03/29 00:00 [accepted]
PHST- 2006/06/09 09:00 [pubmed]
PHST- 2006/09/06 09:00 [medline]
PHST- 2006/06/09 09:00 [entrez]
AID - S1388-2457(06)00154-4 [pii]
AID - 10.1016/j.clinph.2006.03.029 [doi]
PST - ppublish
SO  - Clin Neurophysiol. 2006 Jul;117(7):1481-6. doi: 10.1016/j.clinph.2006.03.029. 
      Epub 2006 Jun 8.