PMID- 16760907
OWN - NLM
STAT- MEDLINE
DCOM- 20061130
LR  - 20221109
IS  - 0085-2538 (Print)
IS  - 0085-2538 (Linking)
VI  - 70
IP  - 3
DP  - 2006 Aug
TI  - CX3CR1+ interstitial dendritic cells form a contiguous network throughout the 
      entire kidney.
PG  - 591-6
AB  - Dendritic cells (DCs) interface innate and adaptive immunity in nonlymphoid 
      organs; however, the exact distribution and types of DC within the kidney are not 
      known. We utilized CX3CR1GFP/+ mice to characterize the anatomy and phenotype of 
      tissue-resident CX3CR1+ DCs within normal kidney. Laser-scanning confocal 
      microscopy revealed an extensive, contiguous network of stellate-shaped CX3CR1+ 
      DCs throughout the interstitial and mesangial spaces of the entire kidney. 
      Intravital microscopy of the superficial cortex showed stationary interstitial 
      CX3CR1+ DCs that continually probe the surrounding tissue environment through 
      dendrite extensions. Flow cytometry of renal CX3CR1+ DCs showed significant 
      coexpression of CD11c and F4/80, high major histocompatibility complex class II 
      and FcR expression, and immature costimulatory but competent phagocytic ability 
      indicative of tissue-resident, immature DCs ready to respond to environment cues. 
      Thus, within the renal parenchyma, there exists little immunological privilege 
      from the surveillance provided by renal CX3CR1+ DCs, a major constituent of the 
      heterogeneous mononuclear phagocyte system populating normal kidney.
FAU - Soos, T J
AU  - Soos TJ
AD  - Division of Nephrology, New York University School of Medicine, New York, New 
      York 10016, USA. soost01@med.nyu.edu
FAU - Sims, T N
AU  - Sims TN
FAU - Barisoni, L
AU  - Barisoni L
FAU - Lin, K
AU  - Lin K
FAU - Littman, D R
AU  - Littman DR
FAU - Dustin, M L
AU  - Dustin ML
FAU - Nelson, P J
AU  - Nelson PJ
LA  - eng
GR  - AI027742/AI/NIAID NIH HHS/United States
GR  - AI033303/AI/NIAID NIH HHS/United States
GR  - AI033856/AI/NIAID NIH HHS/United States
GR  - AI55037/AI/NIAID NIH HHS/United States
GR  - DK065498/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20060607
PL  - United States
TA  - Kidney Int
JT  - Kidney international
JID - 0323470
RN  - 0 (CX3C Chemokine Receptor 1)
RN  - 0 (Cx3cr1 protein, mouse)
RN  - 0 (Receptors, Chemokine)
RN  - 147336-22-9 (Green Fluorescent Proteins)
SB  - IM
CIN - Kidney Int. 2006 Aug;70(3):412-4. PMID: 16871253
MH  - Animals
MH  - CX3C Chemokine Receptor 1
MH  - Cell Communication/*immunology
MH  - Dendritic Cells/*cytology/immunology
MH  - Flow Cytometry
MH  - Green Fluorescent Proteins/genetics
MH  - Immune System/cytology/immunology
MH  - Kidney/*cytology/*immunology
MH  - Mice
MH  - Mice, Transgenic
MH  - Phagocytes/cytology/immunology
MH  - Receptors, Chemokine/genetics/*immunology
EDAT- 2006/06/09 09:00
MHDA- 2006/12/09 09:00
CRDT- 2006/06/09 09:00
PHST- 2006/06/09 09:00 [pubmed]
PHST- 2006/12/09 09:00 [medline]
PHST- 2006/06/09 09:00 [entrez]
AID - S0085-2538(15)51961-3 [pii]
AID - 10.1038/sj.ki.5001567 [doi]
PST - ppublish
SO  - Kidney Int. 2006 Aug;70(3):591-6. doi: 10.1038/sj.ki.5001567. Epub 2006 Jun 7.