PMID- 16760920
OWN - NLM
STAT- MEDLINE
DCOM- 20070405
LR  - 20181201
IS  - 0893-133X (Print)
IS  - 0893-133X (Linking)
VI  - 32
IP  - 3
DP  - 2007 Mar
TI  - Estradiol-induced conditioned place preference may require actions at estrogen 
      receptors in the nucleus accumbens.
PG  - 522-30
AB  - Intrinsic rewarding effects of estradiol (E(2)) may underlie some of the sex 
      differences that emerge postpuberty for the prevalence of drug use and behavioral 
      responses to drugs, but the effects and mechanisms of E(2) for reward have not 
      been well characterized. Conditioned place preference (CPP), as measured by the 
      time spent on the nonpreferred/drug-associated side of the chamber, was utilized 
      as a functional assay to investigate the effects and mechanisms of E(2) in the 
      nucleus accumbens for reward. To determine whether intracellular estrogen 
      receptors (ERs) are important for E(2)-induced CPP, rats were administered E(2) 
      (10 microg; subcutaneously (s.c.)), which produced CPP in each experiment, and/or 
      ER blockers, such as tamoxifen (Experiment 1), ICI 182,780 (Experiment 2), or 
      antisense oligonucleotides targeted to ERs (Experiment 3). Experiment 1: E(2) 
      significantly increased the time spent on the originally nonpreferred side of the 
      chamber. Coadministration of tamoxifen (10 mg/kg; s.c.) attenuated effects of 
      E(2) to produce a CPP, but tamoxifen alone, increased time spent on the 
      nonpreferred side. Experiment 2: coadministration of ICI 182,780 (10 
      microg/microl) to the nucleus accumbens attenuated effects of E(2) to enhance CPP 
      and did not produce a CPP when administered alone. Experiment 3: coadministration 
      of s.c. E(2) with ER antisense oligonucleotides to the nucleus accumbens 
      significantly decreased time spent on the nonpreferred side and expression of ERs 
      in the nucleus accumbens compared to scrambled antisense oligonucleotides or 
      saline vehicle administration. Thus, E(2)'s rewarding effects may involve actions 
      at ERs in the nucleus accumbens.
FAU - Walf, Alicia A
AU  - Walf AA
AD  - Department of Psychology, The University at Albany - SUNY, Albany, NY 12222, USA.
FAU - Rhodes, Madeline E
AU  - Rhodes ME
FAU - Meade, Jonathan R
AU  - Meade JR
FAU - Harney, Jacob P
AU  - Harney JP
FAU - Frye, Cheryl A
AU  - Frye CA
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060607
PL  - England
TA  - Neuropsychopharmacology
JT  - Neuropsychopharmacology : official publication of the American College of 
      Neuropsychopharmacology
JID - 8904907
RN  - 0 (Estrogen Antagonists)
RN  - 0 (Oligonucleotides, Antisense)
RN  - 0 (Receptors, Estrogen)
RN  - 094ZI81Y45 (Tamoxifen)
RN  - 22X328QOC4 (Fulvestrant)
RN  - 4TI98Z838E (Estradiol)
SB  - IM
MH  - Animals
MH  - Behavior, Animal
MH  - Conditioning, Operant/*drug effects/*physiology
MH  - Drug Administration Routes
MH  - Drug Interactions
MH  - Estradiol/administration & dosage/analogs & derivatives/*pharmacology
MH  - Estrogen Antagonists/administration & dosage
MH  - Female
MH  - Fulvestrant
MH  - Nucleus Accumbens/drug effects/*metabolism
MH  - Oligonucleotides, Antisense/pharmacology
MH  - Ovariectomy/methods
MH  - Rats
MH  - Rats, Long-Evans
MH  - Receptors, Estrogen/chemistry/*physiology
MH  - Tamoxifen/administration & dosage
EDAT- 2006/06/09 09:00
MHDA- 2007/04/06 09:00
CRDT- 2006/06/09 09:00
PHST- 2006/06/09 09:00 [pubmed]
PHST- 2007/04/06 09:00 [medline]
PHST- 2006/06/09 09:00 [entrez]
AID - 1301124 [pii]
AID - 10.1038/sj.npp.1301124 [doi]
PST - ppublish
SO  - Neuropsychopharmacology. 2007 Mar;32(3):522-30. doi: 10.1038/sj.npp.1301124. Epub 
      2006 Jun 7.