PMID- 1676171
OWN - NLM
STAT- MEDLINE
DCOM- 19910731
LR  - 20220225
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 38
IP  - 2
DP  - 1991 Feb
TI  - Effects of 3,4-methylenedioxymethamphetamine on autonomic thermoregulatory 
      responses of the rat.
PG  - 339-44
AB  - 3,4-Methylenedioxymethamphetamine (MDMA), a substituted amphetamine analogue 
      which stimulates serotonin release in the CNS, has been shown to induce near 
      lethal elevations in core temperature in the rat. To characterize the effects of 
      MDMA on temperature regulation, we measured metabolic rate (MR), evaporative 
      water loss (EWL), motor activity (MA), and colonic temperature (Tc) in male, 
      Long-Evans rats at 60 min following 30 mg/kg (SC) MDMA or saline at ambient 
      temperature (Ta) of 10, 20 and 30 degrees C. MDMA caused an elevation in MR at 
      Ta's of 20 and 30 degrees C but had no effect at 10 degrees C. At a Ta of 30 
      degrees C, MR of the MDMA group was double that of the saline group. EWL was 
      elevated by MDMA, an effect which was potentiated with increasing Ta. MDMA also 
      elicited an increase in MA at all three Ta's. MDMA led to a 3.2 degrees C 
      increase in Tc at 30 degrees C, no change in Tc at 20 degrees C, and a 2.0 
      degrees C decrease in Tc at 10 degrees C. A second study found that treatment 
      with 20 mg/kg MDMA failed to elicit an increase in blood flow to the tail in 
      spite of a hyperthermic core temperature of 41.4 degrees C. Preliminary studies 
      using radiotelemetry methodology suggested that MDMA lethality is preceded by 
      precipitous elevations in heart rate and core temperature. The data suggest that, 
      at relatively warm Ta's. MDMA-induced stimulation of serotonergic pathways causes 
      an elevation in MR and peripheral vasoconstriction, thus producing 
      life-threatening elevations in Tc.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Gordon, C J
AU  - Gordon CJ
AD  - Neurotoxicology Division, U.S. Environmental Protection Agency, Research Triangle 
      Park, NC 27711.
FAU - Watkinson, W P
AU  - Watkinson WP
FAU - O'Callaghan, J P
AU  - O'Callaghan JP
FAU - Miller, D B
AU  - Miller DB
LA  - eng
GR  - IAG RA89-4/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/*analogs & derivatives/pharmacology/toxicity
MH  - Animals
MH  - Autonomic Nervous System/*drug effects
MH  - Body Temperature/drug effects
MH  - Body Temperature Regulation/*drug effects
MH  - Electrocardiography
MH  - Heart Rate/drug effects
MH  - Male
MH  - Motor Activity/drug effects
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - Rats
MH  - Regional Blood Flow/drug effects
MH  - Tail/blood supply
MH  - Telemetry
EDAT- 1991/02/01 00:00
MHDA- 1991/02/01 00:01
CRDT- 1991/02/01 00:00
PHST- 1991/02/01 00:00 [pubmed]
PHST- 1991/02/01 00:01 [medline]
PHST- 1991/02/01 00:00 [entrez]
AID - 0091-3057(91)90288-D [pii]
AID - 10.1016/0091-3057(91)90288-d [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 1991 Feb;38(2):339-44. doi: 
      10.1016/0091-3057(91)90288-d.