PMID- 16762017
OWN - NLM
STAT- MEDLINE
DCOM- 20060829
LR  - 20060609
IS  - 0904-2512 (Print)
IS  - 0904-2512 (Linking)
VI  - 35
IP  - 6
DP  - 2006 Jul
TI  - Expression of tumor-associated antigen RCAS1 and its possible involvement in 
      immune evasion in oral squamous cell carcinoma.
PG  - 361-8
AB  - BACKGROUND: RCAS1 (receptor-binding cancer antigen expressed on SiSo cells) is 
      known to induce apoptosis in its receptor-positive cells. The authors 
      investigated RCAS1 expression in oral squamous cell carcinoma (SCC) and its 
      association with the apoptosis of tumor-infiltrating lymphocytes (TILs). METHODS: 
      In 130 patients with oral SCC, the expression of RCAS1 in tumor cells was 
      immunohistochemically examined and the apoptosis of TILs was examined by Terminal 
      Deoxynucleotidyltransferase-mediated dUTP Nick End Labeling (TUNEL) staining. 
      RESULTS: RCAS1 was detected both on the cytoplasm and the membrane of tumor cells 
      in 41 of 130 cases (31.5%). Focusing on the expression at the invasive front 
      interacting with host immune cells, RCAS1 was detected in 22 of 130 cases 
      (16.9%). The percentage of TUNEL-positive TILs in cases with RCAS1-positive SCCs 
      was significantly higher than in cases with RCAS1-negative SCCs (P < 0.0001). 
      CONCLUSIONS: RCAS1 can be expressed on oral SCC cells and may be involved in the 
      tumor escape from the host immune system by inducing the apoptosis of TILs.
FAU - Toyoshima, T
AU  - Toyoshima T
AD  - Section of Oral and Maxillofacial Surgery, Division of Maxillofacial Diagnostic 
      and Surgical Sciences, Faculty of Dental Science, Kyushu University, 3-1-1 
      Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
FAU - Nakamura, S
AU  - Nakamura S
FAU - Kumamaru, W
AU  - Kumamaru W
FAU - Kawamura, E
AU  - Kawamura E
FAU - Ishibashi, H
AU  - Ishibashi H
FAU - Hayashida, J-N
AU  - Hayashida JN
FAU - Moriyama, M
AU  - Moriyama M
FAU - Ohyama, Y
AU  - Ohyama Y
FAU - Sasaki, M
AU  - Sasaki M
FAU - Shirasuna, K
AU  - Shirasuna K
LA  - eng
PT  - Journal Article
PL  - Denmark
TA  - J Oral Pathol Med
JT  - Journal of oral pathology & medicine : official publication of the International 
      Association of Oral Pathologists and the American Academy of Oral Pathology
JID - 8911934
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (EBAG9 protein, human)
SB  - IM
MH  - Aged
MH  - Antigens, Neoplasm/*biosynthesis/*physiology
MH  - Apoptosis
MH  - Carcinoma, Squamous Cell/*immunology
MH  - Chi-Square Distribution
MH  - Female
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Immunologic Surveillance
MH  - In Situ Nick-End Labeling
MH  - Lymphocytes, Tumor-Infiltrating/immunology
MH  - Male
MH  - Middle Aged
MH  - Mouth Neoplasms/*immunology
MH  - Prognosis
MH  - Statistics, Nonparametric
MH  - Tumor Escape/*immunology
EDAT- 2006/06/10 09:00
MHDA- 2006/08/30 09:00
CRDT- 2006/06/10 09:00
PHST- 2006/06/10 09:00 [pubmed]
PHST- 2006/08/30 09:00 [medline]
PHST- 2006/06/10 09:00 [entrez]
AID - JOP442 [pii]
AID - 10.1111/j.1600-0714.2006.00442.x [doi]
PST - ppublish
SO  - J Oral Pathol Med. 2006 Jul;35(6):361-8. doi: 10.1111/j.1600-0714.2006.00442.x.