PMID- 16764631
OWN - NLM
STAT- MEDLINE
DCOM- 20060818
LR  - 20131121
IS  - 0934-0874 (Print)
IS  - 0934-0874 (Linking)
VI  - 19
IP  - 7
DP  - 2006 Jul
TI  - Regulatory dendritic cell therapy in organ transplantation.
PG  - 525-38
AB  - Dendritic cells (DCs) are uniquely well equipped antigen (Ag)-presenting cells. 
      Their classic function was thought to be that of potent initiators of innate and 
      adaptive immunity to infectious organisms and other Ags (including transplanted 
      organs). Evidence has emerged, however, that DCs have a central and crucial role 
      in determining the fate of immune responses toward either immunity or tolerance. 
      This dichotomous function of DCs, coupled with their remarkable plasticity, 
      renders them attractive therapeutic targets for immune modulation. In 
      transplantation, much recent work has focused on the ability of DCs to silence 
      immune reactivity in an Ag-specific manner in the hope of preventing rejection 
      and diminishing reliance on potentially harmful immunosuppressive agents. 
      Experimental strategies have included in vivo targeting of DCs, as well as ex 
      vivo generation of regulatory (or tolerogenic) DCs with subsequent reinfusion 
      (i.e. cell therapy). Different approaches to 'program' DC toward tolerogenic 
      properties include genetic (transgene insertion), biologic (differential culture 
      conditions, anti-inflammatory cytokine exposure) and pharmacologic manipulation. 
      Recent data suggest a promising role for pharmacologic treatment as a means of 
      generating potent regulatory DCs and have further stimulated speculation 
      regarding their potential clinical application. Herein, we discuss evidence that 
      the potential of regulatory DC therapy is considerable and that there are 
      compelling reasons to evaluate it in the setting of organ transplantation in the 
      near future.
FAU - McCurry, Kenneth R
AU  - McCurry KR
AD  - Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical 
      Center, Pittsburgh, PA 15213, USA. mccurrykr@upmc.edu
FAU - Colvin, Bridget L
AU  - Colvin BL
FAU - Zahorchak, Alan F
AU  - Zahorchak AF
FAU - Thomson, Angus W
AU  - Thomson AW
LA  - eng
GR  - AI 41101/AI/NIAID NIH HHS/United States
GR  - AI15169/AI/NIAID NIH HHS/United States
GR  - DK 49745/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Switzerland
TA  - Transpl Int
JT  - Transplant international : official journal of the European Society for Organ 
      Transplantation
JID - 8908516
RN  - 0 (Cytokines)
RN  - 1C6V77QF41 (Cholecalciferol)
SB  - IM
MH  - Animals
MH  - Antigen-Presenting Cells
MH  - Cell Lineage
MH  - Cholecalciferol/metabolism
MH  - Cytokines/metabolism
MH  - Dendritic Cells/*cytology
MH  - Graft Rejection
MH  - Humans
MH  - Immune Tolerance
MH  - Inflammation
MH  - Organ Transplantation/*methods
MH  - Transplantation Immunology
MH  - Transplantation Tolerance
RF  - 115
EDAT- 2006/06/13 09:00
MHDA- 2006/08/19 09:00
CRDT- 2006/06/13 09:00
PHST- 2006/06/13 09:00 [pubmed]
PHST- 2006/08/19 09:00 [medline]
PHST- 2006/06/13 09:00 [entrez]
AID - TRI306 [pii]
AID - 10.1111/j.1432-2277.2006.00306.x [doi]
PST - ppublish
SO  - Transpl Int. 2006 Jul;19(7):525-38. doi: 10.1111/j.1432-2277.2006.00306.x.