PMID- 16764689
OWN - NLM
STAT- MEDLINE
DCOM- 20071024
LR  - 20240413
IS  - 0019-2805 (Print)
IS  - 1365-2567 (Electronic)
IS  - 0019-2805 (Linking)
VI  - 119
IP  - 1
DP  - 2006 Sep
TI  - Pregnancy, but not the allergic status, influences spontaneous and induced 
      interleukin-1beta (IL-1beta), IL-6, IL-10 and IL-12 responses.
PG  - 18-26
AB  - In this study, we investigated how pregnancy influences cytokine production in 
      response to stimulation of the innate and the adaptive immune system, 
      respectively. Peripheral blood mononuclear cells (PBMCs) from allergic (n = 44) 
      and non-allergic (n = 36) women were collected at three time-points: during the 
      third trimester, at delivery and at a non-pregnant state 2 years after delivery. 
      The production of interleukin-1beta (IL-1beta), IL-6, IL-10 and IL-12 was 
      measured by enzyme-linked immunosorbent assay (ELISA) or enzyme-linked immunospot 
      assay (ELISPOT). The spontaneous cytokine production, and the response following 
      stimulation with agents that primarily activate the adaptive part of the immune 
      system [phytohaemagglutinin (PHA), allergen extracts from cat and birch], or 
      lipopolysaccharide (LPS) that activate innate immunity was measured in vitro. 
      There was a significantly higher spontaneous in vitro production of IL-1beta, 
      IL-6 and IL-10 by PBMCs during pregnancy than 2 years after pregnancy, and this 
      was not affected by the allergic status of the women. Conversely, in 
      PHA-stimulated cell cultures there was a lower production of IL-10 and IL-12 
      during pregnancy than 2 years after pregnancy. LPS-induced IL-6 levels were 
      significantly lower in PBMCs obtained during pregnancy than at 2 years after 
      pregnancy. In addition, we made the interesting observation that in allergic 
      women total immunoglobulin E (IgE) levels were significantly lower 2 years after 
      pregnancy compared to the levels during pregnancy. Taken together, our results 
      indicate that while atopic allergy in women does not have a substantial effect on 
      cytokine production, pregnancy has an obvious effect on the immune system in 
      terms of cytokine production as well as on the total IgE levels.
FAU - Amoudruz, Petra
AU  - Amoudruz P
AD  - Department of Immunology, Wenner-Gren Institute, Stockholm University, Stockholm, 
      Sweden. petra.amoudruz@imun.su.se
FAU - Minang, Jacob Taku
AU  - Minang JT
FAU - Sundstrom, Yvonne
AU  - Sundstrom Y
FAU - Nilsson, Caroline
AU  - Nilsson C
FAU - Lilja, Gunnar
AU  - Lilja G
FAU - Troye-Blomberg, Marita
AU  - Troye-Blomberg M
FAU - Sverremark-Ekstrom, Eva
AU  - Sverremark-Ekstrom E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060608
PL  - England
TA  - Immunology
JT  - Immunology
JID - 0374672
RN  - 0 (Allergens)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Interleukin-1beta)
RN  - 0 (Interleukin-6)
RN  - 0 (Interleukins)
RN  - 0 (Lipopolysaccharides)
RN  - 130068-27-8 (Interleukin-10)
RN  - 187348-17-0 (Interleukin-12)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - NI40JAQ945 (Tetradecanoylphorbol Acetate)
SB  - IM
MH  - Adult
MH  - Allergens/pharmacology
MH  - Case-Control Studies
MH  - Cells, Cultured
MH  - Enzyme-Linked Immunosorbent Assay/methods
MH  - Female
MH  - Humans
MH  - Hypersensitivity/*immunology
MH  - Immunoglobulin E/blood
MH  - Immunoglobulin G/blood
MH  - Interleukin-10/immunology
MH  - Interleukin-12/immunology
MH  - Interleukin-1beta/immunology
MH  - Interleukin-6/immunology
MH  - Interleukins/*immunology
MH  - Labor, Obstetric/immunology
MH  - Leukocytes, Mononuclear/*immunology
MH  - Lipopolysaccharides/pharmacology
MH  - Postpartum Period/immunology
MH  - Pregnancy
MH  - Pregnancy Complications/*immunology
MH  - Pregnancy Trimester, Third
MH  - Statistics, Nonparametric
MH  - Tetradecanoylphorbol Acetate/pharmacology
PMC - PMC1782335
EDAT- 2006/06/13 09:00
MHDA- 2007/10/25 09:00
PMCR- 2007/09/01
CRDT- 2006/06/13 09:00
PHST- 2006/06/13 09:00 [pubmed]
PHST- 2007/10/25 09:00 [medline]
PHST- 2006/06/13 09:00 [entrez]
PHST- 2007/09/01 00:00 [pmc-release]
AID - IMM2400 [pii]
AID - 10.1111/j.1365-2567.2006.02400.x [doi]
PST - ppublish
SO  - Immunology. 2006 Sep;119(1):18-26. doi: 10.1111/j.1365-2567.2006.02400.x. Epub 
      2006 Jun 8.