PMID- 16765590 OWN - NLM STAT- MEDLINE DCOM- 20061017 LR - 20220408 IS - 0959-8049 (Print) IS - 0959-8049 (Linking) VI - 42 IP - 12 DP - 2006 Aug TI - Past chlamydial infection is not associated with primary fallopian tube carcinoma. PG - 1835-8 AB - We conducted a retrospective seroepidemiological study to evaluate the relationship between past chlamydial infection and primary fallopian tube carcinoma (PFTC). Postoperative serum samples were drawn from 79 consecutive patients treated for PFTC in 1985-2000. For each case two controls were selected. Serum samples were analysed for IgG antibodies to different C. trachomatis serotype pools and to C. pneumoniae. Seropositivity in general or serum antibody levels to different C. trachomatis serovars or C. pneumoniae did not differ between PFTC patients and controls. The lack of association between anti-chlamydial antibodies and PFTC suggests that past chlamydial infection does not play a role in the etiopathogenesis of PFTC. However, because chlamydial infection is common at young age and PFTC develops decades later, we cannot definitively exclude the possibility that C.trachomatis contributes to the development of PFTC. FAU - Riska, A AU - Riska A AD - Department of Obstetrics and Gynaecology, Helsinki University Hospital, Haartmaninkatu 2, 00290, Finland. annika.riska@hus.fi FAU - Finne, P AU - Finne P FAU - Alfthan, H AU - Alfthan H FAU - Anttila, T AU - Anttila T FAU - Jalkanen, J AU - Jalkanen J FAU - Sorvari, T AU - Sorvari T FAU - Stenman, U H AU - Stenman UH FAU - Paavonen, J AU - Paavonen J FAU - Leminen, A AU - Leminen A LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20060612 PL - England TA - Eur J Cancer JT - European journal of cancer (Oxford, England : 1990) JID - 9005373 RN - 0 (Antigens, Bacterial) SB - IM MH - Adult MH - Aged MH - Aged, 80 and over MH - Antigens, Bacterial/analysis MH - Case-Control Studies MH - Chlamydia Infections/*complications MH - Chlamydia trachomatis/immunology MH - Chlamydophila pneumoniae/immunology MH - Fallopian Tube Neoplasms/*microbiology MH - Female MH - Humans MH - Middle Aged MH - Retrospective Studies EDAT- 2006/06/13 09:00 MHDA- 2006/10/18 09:00 CRDT- 2006/06/13 09:00 PHST- 2005/11/24 00:00 [received] PHST- 2005/11/29 00:00 [accepted] PHST- 2006/06/13 09:00 [pubmed] PHST- 2006/10/18 09:00 [medline] PHST- 2006/06/13 09:00 [entrez] AID - S0959-8049(06)00339-X [pii] AID - 10.1016/j.ejca.2005.11.041 [doi] PST - ppublish SO - Eur J Cancer. 2006 Aug;42(12):1835-8. doi: 10.1016/j.ejca.2005.11.041. Epub 2006 Jun 12.