PMID- 16767421
OWN - NLM
STAT- MEDLINE
DCOM- 20070709
LR  - 20181113
IS  - 0033-3158 (Print)
IS  - 0033-3158 (Linking)
VI  - 187
IP  - 1
DP  - 2006 Jul
TI  - Central injections of CRF reinstate cocaine seeking in rats after postinjection 
      delays of up to 3 h: an influence of time and environmental context.
PG  - 112-20
AB  - RATIONALE: In drug addicts, the induction of drug craving is not always 
      associated with an immediate opportunity to take drugs again. It is, therefore, 
      important to study how delays in opportunity for drug seeking affect the 
      time-course of relapse. Intracerebroventricular (i.c.v.) injection of 
      corticotropin-releasing factor (CRF) is a stressor that reinstates heroin and 
      alcohol seeking in rats, when administered just before tests for reinstatement. 
      It is not known whether CRF reinstates cocaine seeking; moreover, the effect of 
      delaying testing for reinstatement, after CRF injection, has not been studied. 
      OBJECTIVES: To determine whether i.c.v. CRF induces reinstatement of cocaine 
      seeking after postinjection delays of up to 3 h and to determine whether the 
      context in which a delay is experienced influences the time-course of CRF-induced 
      reinstatement. METHODS: Rats self-administered cocaine (1.0 mg/kg per infusion) 
      for 8-10 days. Subsequently, responding for drug was extinguished and testing for 
      reinstatement by i.c.v. CRF (0.5 microg) was conducted. Animals were tested after 
      postinjection delays of up to 3 h; the delays were experienced either in the 
      self-administration (SA) chamber or home cage (HC). RESULTS: When delays were 
      spent in the SA chambers, CRF induced reinstatement in all delay groups. When 
      delays were spent in the HC, CRF did not induce reinstatement after a 2-h delay. 
      CONCLUSIONS: We argue that the effects we observed are consistent with a 
      contextual conditioning account of reinstatement, whereby CRF that was 
      experienced in the context of the SA chamber served to elicit a conditioned 
      excitatory response developed to that context during training.
FAU - Erb, Suzanne
AU  - Erb S
AD  - Centre for the Neurobiology of Stress, Department of Life Science, University of 
      Toronto at Scarborough, 1265 Military Trail, Toronto, ON M1C 1A4, Canada. 
      erb@utsc.utoronto.ca
FAU - Petrovic, Ana
AU  - Petrovic A
FAU - Yi, Daniel
AU  - Yi D
FAU - Kayyali, Hanan
AU  - Kayyali H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060503
PL  - Germany
TA  - Psychopharmacology (Berl)
JT  - Psychopharmacology
JID - 7608025
RN  - 9015-71-8 (Corticotropin-Releasing Hormone)
RN  - I5Y540LHVR (Cocaine)
SB  - IM
MH  - Animals
MH  - Brain/*drug effects/physiology
MH  - Cocaine/*administration & dosage
MH  - Corticotropin-Releasing Hormone/*pharmacology
MH  - Injections, Intraventricular
MH  - Male
MH  - Rats
MH  - Rats, Long-Evans
MH  - Recurrence
MH  - *Self Administration
MH  - Time Factors
EDAT- 2006/06/13 09:00
MHDA- 2007/07/10 09:00
CRDT- 2006/06/13 09:00
PHST- 2006/01/29 00:00 [received]
PHST- 2006/03/21 00:00 [accepted]
PHST- 2006/06/13 09:00 [pubmed]
PHST- 2007/07/10 09:00 [medline]
PHST- 2006/06/13 09:00 [entrez]
AID - 10.1007/s00213-006-0392-5 [doi]
PST - ppublish
SO  - Psychopharmacology (Berl). 2006 Jul;187(1):112-20. doi: 
      10.1007/s00213-006-0392-5. Epub 2006 May 3.