PMID- 16767476 OWN - NLM STAT- MEDLINE DCOM- 20070501 LR - 20181113 IS - 0020-9554 (Print) IS - 0020-9554 (Linking) VI - 47 IP - 6 DP - 2006 Jun TI - [Lung cancer]. PG - 611-20; quiz 621 AB - Although various benign and malignant tumors can occur in the bronchi and lungs, lung cancer is by far the most common tumor and the leading cause of tumor death worldwide. For therapeutic reasons lung cancer is classified currently as small cell (SCLC) or non small cell lung cancer (NSCLC). The main cause is smoking. There are no specific symptoms that enable early detection. Staging is according to the international TNM-system. As the results of therapy to date are disappointing and many questions remain unsolved, as many patients as possible should be included in further prospective trials. In SCLC polychemotherapy is mandatory; in local tumor stages radiotherapy should be combined early on with chemotherapy, and in cases of complete remission, prophylactic cranial irradiation is indicated. In operable stages of NSCLC adjuvant chemotherapy demonstrates a survival benefit. In locally advanced NSCLC, radiochemotherapy is now the standard of care. Advanced stages require chemotherapy usually with two drugs, second-line chemotherapy is indicated in cases of relapse. FAU - Huber, R M AU - Huber RM AD - Pneumologie, Klinikum der Universitat - Innenstadt, Ziemssenstrasse 1, 80336 Munchen, Germany. pneumologie@med.uni-muenchen.de LA - ger PT - English Abstract PT - Journal Article PT - Review TT - Lungenkarzinom. PL - Germany TA - Internist (Berl) JT - Der Internist JID - 0264620 SB - IM MH - Antineoplastic Combined Chemotherapy Protocols/*administration & dosage MH - Clinical Trials as Topic/trends MH - Combined Modality Therapy MH - Drug Therapy/*trends MH - Humans MH - Lung Neoplasms/*diagnosis/*therapy MH - Practice Guidelines as Topic MH - Practice Patterns, Physicians'/trends MH - Radiotherapy/*trends MH - Treatment Outcome RF - 16 EDAT- 2006/06/13 09:00 MHDA- 2007/05/02 09:00 CRDT- 2006/06/13 09:00 PHST- 2006/06/13 09:00 [pubmed] PHST- 2007/05/02 09:00 [medline] PHST- 2006/06/13 09:00 [entrez] AID - 10.1007/s00108-006-1581-3 [doi] PST - ppublish SO - Internist (Berl). 2006 Jun;47(6):611-20; quiz 621. doi: 10.1007/s00108-006-1581-3.