PMID- 16767676
OWN - NLM
STAT- MEDLINE
DCOM- 20090327
LR  - 20211203
IS  - 1003-9406 (Print)
IS  - 1003-9406 (Linking)
VI  - 23
IP  - 3
DP  - 2006 Jun
TI  - [The investigation of STK15 gene amplification and overexpression in laryngeal 
      squamous cell carcinoma].
PG  - 326-9
AB  - OBJECTIVE: To investigate the role of STK15 gene amplification and overexpression 
      to genesis and development of laryngeal squamous cell carcinoma (LSCC). METHODS: 
      STK15 gene amplification in 40 cases carcinoma tissues and normal tissues as 
      control was detected by differential PCR approach. STK15 mRNA and protein levels 
      were evaluated by reverse transcription-polymerase chain reaction (RT-PCR) and 
      immunohistochemistry method. RESULTS: In 40 LSCC cases, STK15 gene amplification 
      was found in 14 tumor tissues(35%), mRNA overexpression in 27 tumor 
      tissues(67.5%), and protein upregulated in 29 tumor tissues(72.5%). Statistics 
      analysis showed that STK15 gene amplification and mRNA overexpression were 
      obviously associated to differentiation degree of LSCC, and protein 
      overexpression was closely associated with both differentiation degree and 
      pathological grades of LSCC. CONCLUSION: This research results suggest that STK15 
      gene amplification contributes to its mRNA and protein overexpression through 
      affecting the exact replication of centrosome and separation of chromosomes. 
      STK15 gene thus plays a role in LSCC oncogenesis and malignant progression.
FAU - Ye, Yan
AU  - Ye Y
AD  - Department of Medical Genetics, China Medical University, Shenyang, Liaoning, 
      110001 PR China.
FAU - Li, Fu-cai
AU  - Li FC
FAU - Wang, Shu-yun
AU  - Wang SY
FAU - Li, Chan-yuan
AU  - Li CY
FAU - Yuan, Hai-ming
AU  - Yuan HM
FAU - Zhao, Xu
AU  - Zhao X
FAU - Fu, Wei-neng
AU  - Fu WN
FAU - Xu, Zhen-ming
AU  - Xu ZM
FAU - Sun, Kai-lai
AU  - Sun KL
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi
JT  - Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese 
      journal of medical genetics
JID - 9425197
RN  - EC 2.7.11.1 (AURKA protein, human)
RN  - EC 2.7.11.1 (Aurora Kinase A)
RN  - EC 2.7.11.1 (Aurora Kinases)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
SB  - IM
MH  - Aurora Kinase A
MH  - Aurora Kinases
MH  - Carcinoma, Squamous Cell/*genetics/metabolism
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Immunohistochemistry
MH  - Laryngeal Neoplasms/*genetics/metabolism
MH  - Protein Serine-Threonine Kinases/*genetics/metabolism
MH  - Reverse Transcriptase Polymerase Chain Reaction
EDAT- 2006/06/13 09:00
MHDA- 2009/03/28 09:00
CRDT- 2006/06/13 09:00
PHST- 2006/06/13 09:00 [pubmed]
PHST- 2009/03/28 09:00 [medline]
PHST- 2006/06/13 09:00 [entrez]
AID - 940623083 [pii]
PST - ppublish
SO  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2006 Jun;23(3):326-9.