PMID- 16768292
OWN - NLM
STAT- MEDLINE
DCOM- 20060727
LR  - 20190922
IS  - 0920-5063 (Print)
IS  - 1568-5624 (Electronic)
IS  - 0920-5063 (Linking)
VI  - 17
IP  - 4
DP  - 2006
TI  - Fabrication and characterization of poly(DL-lactic-co-glycolic 
      acid)/zirconia-hybridized amorphous calcium phosphate composites.
PG  - 403-18
AB  - Several minerals, such as hydroxyapatite and beta-tricalcium phosphate, have been 
      incorporated into bioresorbable polyester bone scaffolds to increase the 
      osteoconductivity both in vitro and in vivo. More soluble forms of calcium 
      phosphate that release calcium and phosphate ions have been postulated as factors 
      that increase osteoblast differentiation and mineralization. Recently, a 
      zirconia-hybridized pyrophosphate-stabilized amorphous calcium phosphate (Zr-ACP) 
      has been synthesized allowing controlled release of calcium and phosphate ions. 
      When incorporated into bioresorbable scaffolds, Zr-ACP has the potential to 
      induce osteoconductivity. In this study, 80-90% (w/v) porous 
      poly(DL-lactic-co-glycolic acid) (PLGA) scaffolds were formed by thermal phase 
      separation from dioxane while incorporating Zr-ACP. Scanning electron microscopy 
      revealed a highly porous structure with a pore size ranging from a few microm to 
      about 100 microm, smaller than we had hoped for. Zr-ACP particles were evenly 
      dispersed in the composite structure and incorporated into the pore walls. The 
      amorphous structure of the Zr-ACP was maintained during composite fabrication, as 
      found by X-ray diffraction. Composite scaffolds had larger compressive yield 
      strengths and moduli compared to pure polymer scaffolds. These initial efforts 
      demonstrate that PLGA/Zr-ACP composites can be formed in ways that ultimately 
      serve as promising bone scaffolds in tissue engineering.
FAU - Whited, Bryce M
AU  - Whited BM
AD  - School of Biomedical Engineering and Sciences, Virginia Polytechnic Institute and 
      State University, Blacksburg, Virginia 24061-0298, USA.
FAU - Goldstein, Aaron S
AU  - Goldstein AS
FAU - Skrtic, Drago
AU  - Skrtic D
FAU - Love, Brian J
AU  - Love BJ
LA  - eng
GR  - R03 DE015229/DE/NIDCR NIH HHS/United States
GR  - R03 DE015229-01A1/DE/NIDCR NIH HHS/United States
GR  - R03 DE015229-02/DE/NIDCR NIH HHS/United States
GR  - DE-015529/DE/NIDCR NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - England
TA  - J Biomater Sci Polym Ed
JT  - Journal of biomaterials science. Polymer edition
JID - 9007393
RN  - 0 (Bone Substitutes)
RN  - 0 (Calcium Phosphates)
RN  - 0 (Chlorides)
RN  - 0 (Polymers)
RN  - 0 (Solvents)
RN  - 0 (amorphous calcium phosphate)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 26009-03-0 (Polyglycolic Acid)
RN  - 33X04XA5AT (Lactic Acid)
RN  - 97Z1WI3NDX (calcium phosphate)
RN  - C6V6S92N3C (Zirconium)
RN  - Z88176T871 (zirconium chloride)
SB  - IM
MH  - Bone Substitutes/*chemical synthesis/chemistry
MH  - Calcium Phosphates/*chemistry
MH  - Chlorides/*chemistry
MH  - Compressive Strength
MH  - Lactic Acid/*chemistry
MH  - Materials Testing
MH  - Microscopy, Electron, Scanning
MH  - Polyglycolic Acid/*chemistry
MH  - Polylactic Acid-Polyglycolic Acid Copolymer
MH  - Polymers/*chemistry
MH  - Porosity
MH  - Solvents/chemistry
MH  - *Tissue Engineering
MH  - X-Ray Diffraction
MH  - Zirconium/*chemistry
PMC - PMC2962981
MID - NIHMS8937
EDAT- 2006/06/14 09:00
MHDA- 2006/07/28 09:00
PMCR- 2010/10/25
CRDT- 2006/06/14 09:00
PHST- 2006/06/14 09:00 [pubmed]
PHST- 2006/07/28 09:00 [medline]
PHST- 2006/06/14 09:00 [entrez]
PHST- 2010/10/25 00:00 [pmc-release]
AID - 10.1163/156856206776374124 [doi]
PST - ppublish
SO  - J Biomater Sci Polym Ed. 2006;17(4):403-18. doi: 10.1163/156856206776374124.