PMID- 16769066
OWN - NLM
STAT- MEDLINE
DCOM- 20061024
LR  - 20181113
IS  - 0018-506X (Print)
IS  - 1095-6867 (Electronic)
IS  - 0018-506X (Linking)
VI  - 50
IP  - 3
DP  - 2006 Sep
TI  - Nuclear receptor coactivators function in estrogen receptor- and progestin 
      receptor-dependent aspects of sexual behavior in female rats.
PG  - 383-92
AB  - The ovarian hormones, estradiol (E) and progesterone (P) facilitate the 
      expression of sexual behavior in female rats. E and P mediate many of these 
      behavioral effects by binding to their respective intracellular receptors in 
      specific brain regions. Nuclear receptor coactivators, including Steroid Receptor 
      Coactivator-1 (SRC-1) and CREB Binding Protein (CBP), dramatically enhance 
      ligand-dependent steroid receptor transcriptional activity in vitro. Previously, 
      our lab has shown that SRC-1 and CBP modulate estrogen receptor (ER)-mediated 
      induction of progestin receptor (PR) gene expression in the ventromedial nucleus 
      of the hypothalamus (VMN) and hormone-dependent sexual receptivity in female 
      rats. Female sexual behaviors can be activated by high doses of E alone in 
      ovariectomized rats, and thus are believed to be ER-dependent. However, the full 
      repertoire of female sexual behavior, in particular, proceptive behaviors such as 
      hopping, darting and ear wiggling, are considered to be PR-dependent. In the 
      present experiments, the function of SRC-1 and CBP in distinct ER- (Exp. 1) and 
      PR- (Exp. 2) dependent aspects of female sexual behavior was investigated. In 
      Exp. 1, infusion of antisense oligodeoxynucleotides to SRC-1 and CBP mRNA into 
      the VMN decreased lordosis intensity in rats treated with E alone, suggesting 
      that these coactivators modulate ER-mediated female sexual behavior. In Exp. 2, 
      antisense to SRC-1 and CBP mRNA around the time of P administration reduced 
      PR-dependent ear wiggling and hopping and darting. Taken together, these data 
      suggest that SRC-1 and CBP modulate ER and PR action in brain and influence 
      distinct aspects of hormone-dependent sexual behaviors. These findings support 
      our previous studies and provide further evidence that SRC-1 and CBP function 
      together to regulate ovarian hormone action in behaviorally-relevant brain 
      regions.
FAU - Molenda-Figueira, Heather A
AU  - Molenda-Figueira HA
AD  - Center for Neuroendocrine Studies, Neuroscience and Behavior Program, University 
      of Massachusetts, Amherst, MA 01003, USA.
FAU - Williams, Casey A
AU  - Williams CA
FAU - Griffin, Andreana L
AU  - Griffin AL
FAU - Rutledge, Eric M
AU  - Rutledge EM
FAU - Blaustein, Jeffrey D
AU  - Blaustein JD
FAU - Tetel, Marc J
AU  - Tetel MJ
LA  - eng
GR  - R01 DK061935-04/DK/NIDDK NIH HHS/United States
GR  - DK 61935/DK/NIDDK NIH HHS/United States
GR  - R01 DK061935/DK/NIDDK NIH HHS/United States
GR  - T32MH47538/MH/NIMH NIH HHS/United States
GR  - NS 19327/NS/NINDS NIH HHS/United States
GR  - R01 DK061935-03/DK/NIDDK NIH HHS/United States
GR  - R01 DK061935-02/DK/NIDDK NIH HHS/United States
GR  - R01 NS019327/NS/NINDS NIH HHS/United States
GR  - R01 MH047538/MH/NIMH NIH HHS/United States
GR  - R55 DK061935/DK/NIDDK NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Horm Behav
JT  - Hormones and behavior
JID - 0217764
RN  - 0 (Oligodeoxyribonucleotides, Antisense)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Estrogen)
RN  - 0 (Receptors, Progesterone)
RN  - 0 (Transcription Factors)
RN  - EC 2.3.1.48 (CREB-Binding Protein)
RN  - EC 2.3.1.48 (Histone Acetyltransferases)
RN  - EC 2.3.1.48 (Nuclear Receptor Coactivator 1)
SB  - IM
MH  - Animals
MH  - CREB-Binding Protein/analysis/*physiology
MH  - Female
MH  - Histone Acetyltransferases/genetics/*physiology
MH  - Male
MH  - Microinjections
MH  - Nuclear Receptor Coactivator 1
MH  - Oligodeoxyribonucleotides, Antisense/administration & dosage
MH  - Posture
MH  - RNA, Messenger/analysis
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Estrogen/*metabolism
MH  - Receptors, Progesterone/*metabolism
MH  - Sex Factors
MH  - Sexual Behavior, Animal/*physiology
MH  - Transcription Factors/genetics/*physiology
MH  - Ventromedial Hypothalamic Nucleus/drug effects/*metabolism
PMC - PMC2244585
MID - NIHMS37960
EDAT- 2006/06/14 09:00
MHDA- 2006/10/25 09:00
PMCR- 2008/02/14
CRDT- 2006/06/14 09:00
PHST- 2006/01/18 00:00 [received]
PHST- 2006/04/25 00:00 [revised]
PHST- 2006/04/26 00:00 [accepted]
PHST- 2006/06/14 09:00 [pubmed]
PHST- 2006/10/25 09:00 [medline]
PHST- 2006/06/14 09:00 [entrez]
PHST- 2008/02/14 00:00 [pmc-release]
AID - S0018-506X(06)00121-8 [pii]
AID - 10.1016/j.yhbeh.2006.04.005 [doi]
PST - ppublish
SO  - Horm Behav. 2006 Sep;50(3):383-92. doi: 10.1016/j.yhbeh.2006.04.005.