PMID- 16769156
OWN - NLM
STAT- MEDLINE
DCOM- 20090123
LR  - 20091119
IS  - 1558-1497 (Electronic)
IS  - 0197-4580 (Linking)
VI  - 28
IP  - 7
DP  - 2007 Jul
TI  - Effect of aging on the expression of BDNF and TrkB isoforms in rat pituitary.
PG  - 1088-98
AB  - Brain-derived neurotrophic factor (BDNF) is a key regulator of neuronal 
      plasticity in adult rat brain and its effects are mediated through TrkB 
      receptors. BDNF and its receptors are also localized in the pituitary, but their 
      expressions throughout the rat lifespan are poorly known. Here we analyzed levels 
      of BDNF and the different subtypes of TrkB receptors (mRNA and proteins) in the 
      rat pituitary at different stages of life. BDNF immunoreactivity was expressed in 
      folliculo-stellate cells from the anterior pituitary and in the intermediate 
      lobe. TrkB.FL and TrkB.T1 receptors were strongly and essentially expressed in 
      the intermediate lobe similar to the alpha-MSH localization pattern. These 
      receptors begun decreasing at middle-age but TrkB.T2 was not detected in the 
      pituitary at any age. Finally, in vitro alpha-MSH release from the intermediate 
      lobe was correlated with the receptor content throughout the lifespan. The 
      present results demonstrate the presence of BDNF in folliculo-stellate cells and 
      indicated that receptors, rather than BDNF itself, are impaired with aging. These 
      changes can contribute to explain age-dependent endocrine changes.
FAU - Rage, Florence
AU  - Rage F
AD  - IGMM, UMR5535 CNRS, Montpellier Cedex 5, France. florence.rage@igmm.cnrs.fr
FAU - Silhol, Michele
AU  - Silhol M
FAU - Biname, Fabien
AU  - Biname F
FAU - Arancibia, Sandor
AU  - Arancibia S
FAU - Tapia-Arancibia, Lucia
AU  - Tapia-Arancibia L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060610
PL  - United States
TA  - Neurobiol Aging
JT  - Neurobiology of aging
JID - 8100437
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Protein Isoforms)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Aging/*metabolism
MH  - Animals
MH  - Animals, Newborn
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Gene Expression Regulation, Developmental/physiology
MH  - Pituitary Gland/*metabolism
MH  - Protein Isoforms/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor, trkB/*metabolism
MH  - Tissue Distribution
EDAT- 2006/06/14 09:00
MHDA- 2009/01/24 09:00
CRDT- 2006/06/14 09:00
PHST- 2005/11/28 00:00 [received]
PHST- 2006/03/22 00:00 [revised]
PHST- 2006/05/03 00:00 [accepted]
PHST- 2006/06/14 09:00 [pubmed]
PHST- 2009/01/24 09:00 [medline]
PHST- 2006/06/14 09:00 [entrez]
AID - S0197-4580(06)00148-5 [pii]
AID - 10.1016/j.neurobiolaging.2006.05.013 [doi]
PST - ppublish
SO  - Neurobiol Aging. 2007 Jul;28(7):1088-98. doi: 
      10.1016/j.neurobiolaging.2006.05.013. Epub 2006 Jun 10.