PMID- 16769252
OWN - NLM
STAT- MEDLINE
DCOM- 20070209
LR  - 20171116
IS  - 1537-1891 (Print)
IS  - 1537-1891 (Linking)
VI  - 45
IP  - 2
DP  - 2006 Aug
TI  - Dissociation between vascular oxidative stress and cardiovascular function in 
      Wistar Kyoto and spontaneously hypertensive rats.
PG  - 112-21
AB  - It has not been completely demonstrated if hypertension may, in part, develop as 
      a result of increased oxidative stress (OS), inflammation and little is known 
      about the short-term effects of antioxidant therapy. This study was designed to 
      appreciate the effect of 7 days vitamin C-enriched diet (5 g/kg/day) on 
      hemodynamic function and vascular OS in normotensive Wistar Kyoto rats and 
      hypertensive rats (SHR). Aorta NAD(P)H oxidase activity was determinate and free 
      radicals evaluated by electron spin resonance with a spin probe CP-H. Matrix 
      metalloproteinase-1 (MMP-1) and monocyte chemoattractant protein-1 (MCP-1) 
      expression were measured. The treatment with vitamin C did not change arterial 
      pressure in SHR but prevented the increase in OS levels in SHR aortas. MMP-1 and 
      MCP-1 expressions were more intense in the media of SHR aortas than in those of 
      WKY rats but these expressions were not modified by vitamin C-pretreatment. 
      Vitamin C-pretreatment was not able to protect heart against in vitro 
      ischemia-reperfusion dysfunctions. These data may suggest that treatment with 
      high doses of vitamin C in SHR can limit over-production of reactive oxygen 
      species; however this effect was not accompanied with changes in arterial 
      pressure and protection against I-R dysfunctions. Dissociation between vascular 
      oxidative stress and cardiovascular function may be evoked.
FAU - Sicard, Pierre
AU  - Sicard P
AD  - Laboratoire de Physiopathologie et Pharmacologie Cardio-vasculaires 
      Experimentales, IFR no. 100, Facultes de Medecine et de Pharmacie, 7, Boulevard 
      Jeanne d'Arc, 21000 Dijon, France. sicard123@yahoo.fr
FAU - Oudot, Alexandra
AU  - Oudot A
FAU - Guilland, Jean-Claude
AU  - Guilland JC
FAU - Moreau, Daniel
AU  - Moreau D
FAU - Vergely, Catherine
AU  - Vergely C
FAU - Rochette, Luc
AU  - Rochette L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Vascul Pharmacol
JT  - Vascular pharmacology
JID - 101130615
RN  - 0 (Antioxidants)
RN  - 0 (Ccl2 protein, rat)
RN  - 0 (Chemokine CCL2)
RN  - EC 1.6.3.- (NADPH Oxidases)
RN  - EC 3.4.24.7 (Matrix Metalloproteinase 1)
RN  - PQ6CK8PD0R (Ascorbic Acid)
SB  - IM
MH  - Animals
MH  - Antioxidants/metabolism/pharmacology
MH  - Aorta/metabolism
MH  - Ascorbic Acid/blood/metabolism/*pharmacology
MH  - Blood Pressure/drug effects
MH  - Chemokine CCL2/metabolism
MH  - Heart/*drug effects
MH  - *Hypertension/drug therapy/metabolism
MH  - Male
MH  - Matrix Metalloproteinase 1/metabolism
MH  - NADPH Oxidases/metabolism
MH  - Organ Culture Techniques
MH  - Oxidative Stress/*drug effects
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Inbred WKY
MH  - Reperfusion Injury/metabolism
MH  - Time Factors
EDAT- 2006/06/14 09:00
MHDA- 2007/02/10 09:00
CRDT- 2006/06/14 09:00
PHST- 2006/01/09 00:00 [received]
PHST- 2006/04/19 00:00 [revised]
PHST- 2006/04/20 00:00 [accepted]
PHST- 2006/06/14 09:00 [pubmed]
PHST- 2007/02/10 09:00 [medline]
PHST- 2006/06/14 09:00 [entrez]
AID - S1537-1891(06)00101-7 [pii]
AID - 10.1016/j.vph.2006.04.001 [doi]
PST - ppublish
SO  - Vascul Pharmacol. 2006 Aug;45(2):112-21. doi: 10.1016/j.vph.2006.04.001.