PMID- 16770329
OWN - NLM
STAT- MEDLINE
DCOM- 20070423
LR  - 20231212
IS  - 0307-0565 (Print)
IS  - 0307-0565 (Linking)
VI  - 31
IP  - 2
DP  - 2007 Feb
TI  - Increased serum interleukin-18 concentration is associated with 
      hypoadiponectinemia in obesity, independently of insulin resistance.
PG  - 221-5
AB  - OBJECTIVE: Interleukin-18 (IL-18) is a cytokine with proinflammatory and 
      proatherogenic properties, which might be associated with the development of 
      insulin resistance. In contrast, adiponectin, a protein secreted by adipose 
      tissue, might exert insulin-sensitizing and antiatherogenic effects. The aim of 
      the present study was to analyze the association between serum IL-18 and 
      adiponectin in lean and obese subjects, in relation to insulin resistance. 
      DESIGN: Cross-sectional study. SUBJECTS: One hundred and thirty individuals, 62 
      lean (body mass index (BMI)<25 kg/m(2), 30 men and 32 women) and 68 with 
      overweight or obesity (BMI>25 kg/m(2), 24 men and 44 women), with normal glucose 
      tolerance and without concomitant diseases. MEASUREMENTS: Oral glucose tolerance 
      test, euglycemic hyperinsulinemic clamp, serum concentrations of IL-18, IL-6, 
      soluble tumor necrosis factor-alpha receptors and adiponectin. RESULTS: Obese 
      subjects had lower insulin sensitivity (M value, P=0.00029) and serum adiponectin 
      (P=0.01) and higher levels of serum IL-18 (P=0.00055). Circulating IL-18 was 
      negatively related to adiponectin (r=-0.31, P=0.00027) and insulin sensitivity 
      (r=-0.33, P=0.00012). Subgroup analysis revealed that these associations were 
      present in the obese (adiponectin, r=-0.38, P=0.0014; M, r=-0.29, P=0.016), but 
      not in lean individuals (r=-0.17, P=0.18 and r=-0.20, P=0.12, respectively). 
      Association of IL-18 with adiponectin remained significant after adjustment for 
      other estimated parameters, including insulin sensitivity. Also, relationship 
      between IL-18 and insulin sensitivity was independent of other estimated 
      parameters. CONCLUSION: Serum IL-18 is inversely related to serum adiponectin, 
      independently of insulin resistance. The relationships of IL-18 with adiponectin 
      and insulin sensitivity are influenced by the presence of overweight/obesity.
FAU - Straczkowski, M
AU  - Straczkowski M
AD  - Department of Endocrinology, Diabetology and Internal Medicine, Medical 
      University of Bialystok, Bialystok, Poland. mstraczkowski@poczta.onet.pl
FAU - Kowalska, I
AU  - Kowalska I
FAU - Nikolajuk, A
AU  - Nikolajuk A
FAU - Otziomek, E
AU  - Otziomek E
FAU - Adamska, A
AU  - Adamska A
FAU - Karolczuk-Zarachowicz, M
AU  - Karolczuk-Zarachowicz M
FAU - Gorska, M
AU  - Gorska M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060613
PL  - England
TA  - Int J Obes (Lond)
JT  - International journal of obesity (2005)
JID - 101256108
RN  - 0 (Adiponectin)
RN  - 0 (Blood Glucose)
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Adiponectin/*blood
MH  - Adult
MH  - Anthropometry
MH  - Blood Glucose/metabolism
MH  - Body Mass Index
MH  - Cross-Sectional Studies
MH  - Female
MH  - Glucose Tolerance Test
MH  - Humans
MH  - *Insulin Resistance
MH  - Interleukin-18/*blood
MH  - Male
MH  - Obesity/*blood
EDAT- 2006/06/14 09:00
MHDA- 2007/04/24 09:00
CRDT- 2006/06/14 09:00
PHST- 2006/06/14 09:00 [pubmed]
PHST- 2007/04/24 09:00 [medline]
PHST- 2006/06/14 09:00 [entrez]
AID - 0803421 [pii]
AID - 10.1038/sj.ijo.0803421 [doi]
PST - ppublish
SO  - Int J Obes (Lond). 2007 Feb;31(2):221-5. doi: 10.1038/sj.ijo.0803421. Epub 2006 
      Jun 13.