PMID- 16770774
OWN - NLM
STAT- MEDLINE
DCOM- 20061101
LR  - 20071115
IS  - 0360-4012 (Print)
IS  - 0360-4012 (Linking)
VI  - 84
IP  - 3
DP  - 2006 Aug 15
TI  - Decreased expression of brain-derived neurotrophic factor in BDNF(+/-) mice is 
      associated with enhanced recovery of motor performance and increased neuroblast 
      number following experimental stroke.
PG  - 626-31
AB  - Brain-derived neurotrophic factor (BDNF) is involved in brain plasticity and 
      neuronal survival. Generally, BDNF enhances synaptic activity and neurite growth, 
      although the effect of BDNF on neuronal survival and brain plasticity following 
      injury is equivocal. Housing rats in an enriched environment after experimental 
      stroke enhances recovery of sensory-motor function, which is associated with a 
      decrease in the BDNF mRNA and protein levels. We used BDNF(+/-) mice and 
      wild-type littermate mice to investigate whether the decrease in the brain levels 
      of BDNF affected motor function or infarct volume following transient occlusion 
      of the middle cerebral artery (tMCAO) for 40 min. We found that the BDNF(+/-) 
      mice had a significantly improved motor function on the rotating pole test 2 
      weeks after tMCAO compared with wild-type mice. When intermittently exposed to an 
      enriched environment following tMCAO, the wild-type mice improved motor function 
      to the same degree as BDNF(+/-) mice. There was no effect of BDNF reduction on 
      infarct volume. Neurogenesis is induced following experimental stroke, and in the 
      striatum of BDNF(+/-) mice significantly increased numbers of neuroblasts 
      compared with wild-type mice were seen, both in standard and in enriched 
      conditions. We conclude that decreasing brain levels of BDNF enhances the 
      recovery of function following experimental stroke.
FAU - Nygren, Josefine
AU  - Nygren J
AD  - Experimental Brain Research, Wallenberg Neuroscience Center, Lund University, 
      Lund, Sweden. josefine.nygren@med.lu.se
FAU - Kokaia, Merab
AU  - Kokaia M
FAU - Wieloch, Tadeusz
AU  - Wieloch T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci Res
JT  - Journal of neuroscience research
JID - 7600111
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Brain/cytology/*metabolism/pathology
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Cell Count
MH  - Cell Differentiation/genetics
MH  - Cell Proliferation
MH  - Disease Models, Animal
MH  - Down-Regulation/genetics
MH  - Infarction, Middle Cerebral Artery/genetics/metabolism/physiopathology
MH  - Male
MH  - Mice
MH  - Mice, Knockout
MH  - Motor Activity/genetics
MH  - Movement/physiology
MH  - Movement Disorders/etiology/genetics/metabolism
MH  - Neurons/cytology/*metabolism
MH  - Recovery of Function/*genetics
MH  - Stem Cells/cytology/*metabolism
MH  - Stroke/genetics/*metabolism/physiopathology
EDAT- 2006/06/14 09:00
MHDA- 2006/11/02 09:00
CRDT- 2006/06/14 09:00
PHST- 2006/06/14 09:00 [pubmed]
PHST- 2006/11/02 09:00 [medline]
PHST- 2006/06/14 09:00 [entrez]
AID - 10.1002/jnr.20956 [doi]
PST - ppublish
SO  - J Neurosci Res. 2006 Aug 15;84(3):626-31. doi: 10.1002/jnr.20956.