PMID- 16770985
OWN - NLM
STAT- MEDLINE
DCOM- 20060712
LR  - 20131213
IS  - 0025-6196 (Print)
IS  - 0025-6196 (Linking)
VI  - 81
IP  - 6
DP  - 2006 Jun
TI  - Transient left ventricular apical ballooning after cocaine use: is catecholamine 
      cardiotoxicity the pathologic link?
PG  - 829-32
AB  - We describe a patient who developed acute chest pain after using cocaine and had 
      ST-segment elevation in the anterior leads on electrocardiography with mild 
      elevation of cardiac enzymes. Cardiac catheterization showed normal coronary 
      arteries with no coronary vasospasm. Left ventricular angiography revealed 
      typical ballooning of the left ventricular apex during systole with an estimated 
      left ventricular ejection fraction of 25%. The symptoms improved during the next 
      few hours, and follow-up echocardiography 4 days later showed complete resolution 
      of the left ventricular dysfunction. Transient left ventricular apical ballooning 
      (LVAB) was diagnosed. To our knowledge, LVAB (also known as Takotsubo 
      cardiomyopathy or "broken heart syndrome") has not been reported previously in 
      association with cocaine use. We discuss the possible pathophysiologic link 
      between LVAB and cocaine-induced cardiotoxicity.
FAU - Arora, Sandeep
AU  - Arora S
AD  - Department of Internal Medicine, Western Pennsylvania Hospital/Temple University 
      Program, 4800 Friendship Ave, Pittsburgh, PA 15224, USA. 
      sandeeparora24@hotmail.com
FAU - Alfayoumi, Fadi
AU  - Alfayoumi F
FAU - Srinivasan, Venkatraman
AU  - Srinivasan V
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Mayo Clin Proc
JT  - Mayo Clinic proceedings
JID - 0405543
RN  - 0 (Catecholamines)
RN  - 0 (Crack Cocaine)
SB  - IM
CIN - Mayo Clin Proc. 2006 Jun;81(6):732-5. PMID: 16770972
MH  - Cardiomyopathies/*chemically induced/diagnosis/*physiopathology
MH  - Catecholamines/*blood
MH  - Crack Cocaine/*adverse effects/blood
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Syndrome
MH  - Ventricular Dysfunction, Left/*chemically induced/diagnosis/*physiopathology
EDAT- 2006/06/15 09:00
MHDA- 2006/07/13 09:00
CRDT- 2006/06/15 09:00
PHST- 2006/06/15 09:00 [pubmed]
PHST- 2006/07/13 09:00 [medline]
PHST- 2006/06/15 09:00 [entrez]
AID - S0025-6196(11)61739-4 [pii]
AID - 10.4065/81.6.829 [doi]
PST - ppublish
SO  - Mayo Clin Proc. 2006 Jun;81(6):829-32. doi: 10.4065/81.6.829.