PMID- 16772124
OWN - NLM
STAT- MEDLINE
DCOM- 20060727
LR  - 20131121
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 168
IP  - 1
DP  - 2006 Jul 1
TI  - A t(17;20)(q21;q12) masking a variant t(15;17)(q22;q21) in a patient with acute 
      promyelocytic leukemia.
PG  - 73-6
AB  - Acute promyelocytic leukemia (APL) is genetically characterized by a reciprocal 
      translocation between chromosomes 15 and 17, the t(15;17)(q22;q21), which results 
      in the fusion gene PML/RARA. A small proportion of patients with APL have complex 
      or simple variants of this translocation. We report the case of a 31-year-old 
      woman with APL (FAB-M3 classical form) carrying an apparently balanced 
      translocation t(17;20)(q21;q12) masking a t(15;17)(q22;q21) confirmed by 
      fluorescence in situ hybridization (FISH) and molecular studies. The patient was 
      treated with an all-trans-retinoic acid (ATRA) plus anthracycline-based protocol 
      and achieved complete remission, with no recurrence to date. These results 
      illustrate the usefulness of combining cytogenetics, FISH, and reverse 
      transcription-polymerase chain reaction (RT-PCR) methods to evidence the PML/RARA 
      fusion gene in cases with morphologic suspicion of APL with variant or cryptic 
      t(15;17).
FAU - Garcia-Casado, Zaida
AU  - Garcia-Casado Z
AD  - Department of Hematology, Hospital Universitario La Fe, Avenida Campanar, 21, 
      46009 Valencia, Spain.
FAU - Cervera, Jose
AU  - Cervera J
FAU - Valencia, Ana
AU  - Valencia A
FAU - Pajuelo, Juan C
AU  - Pajuelo JC
FAU - Mena-Duran, Armando V
AU  - Mena-Duran AV
FAU - Barragan, Eva
AU  - Barragan E
FAU - Bolufer, Pascual
AU  - Bolufer P
FAU - Sanz, Miguel A
AU  - Sanz MA
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (Anthracyclines)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Oncogene Proteins, Fusion)
RN  - 0 (promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein)
RN  - 5688UTC01R (Tretinoin)
SB  - IM
MH  - Adult
MH  - Anthracyclines/therapeutic use
MH  - Chromosome Painting
MH  - Chromosomes, Human, Pair 15/*genetics
MH  - Chromosomes, Human, Pair 17/*genetics
MH  - Chromosomes, Human, Pair 20/*genetics
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia, Promyelocytic, Acute/drug therapy/*genetics
MH  - Neoplasm Proteins/genetics
MH  - Oncogene Proteins, Fusion/genetics
MH  - Remission Induction
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Translocation, Genetic/*genetics
MH  - Tretinoin/therapeutic use
EDAT- 2006/06/15 09:00
MHDA- 2006/07/28 09:00
CRDT- 2006/06/15 09:00
PHST- 2005/11/10 00:00 [received]
PHST- 2005/12/19 00:00 [revised]
PHST- 2005/12/29 00:00 [accepted]
PHST- 2006/06/15 09:00 [pubmed]
PHST- 2006/07/28 09:00 [medline]
PHST- 2006/06/15 09:00 [entrez]
AID - S0165-4608(06)00002-1 [pii]
AID - 10.1016/j.cancergencyto.2005.12.014 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2006 Jul 1;168(1):73-6. doi: 
      10.1016/j.cancergencyto.2005.12.014.